A review of the treatment of bone tumours by hyperthermia using magnetic nanoparticles
Subject Areas : Journal of NanoanalysisAthena Ehsani 1 , Rayappa Shrinivas Mahale 2 , Shika Shayegan 3 , Ali Attaeyan 4 , Atefeh Ghorbani 5 , Shamanth Vasanth 6 , Sharath P C 7 , Sheyda Shahriari 8 , Azadeh Asefnejad 9
1 - Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - School of Mechanical Engineering, REVA University, Bengaluru, Karnataka, India
3 - Department of Pharmacy, Cyprus Health and Social Science, Guzelyurt, TRNC via Mersin 10, Turkey
4 - Faculty of Biomechanics, Department of Biomedical Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
5 - Biotechnology Department,Falavarjan Branch, lslamic Azad University,Esfahan,lran
6 - School of Mechanical Engineering, REVA University, Bengaluru, Karnataka, India
7 - Department of Metallurgical and Materials Engineering, JAIN Deemed to be University Bangalore Karnataka, India
8 - Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK
9 - Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Keywords: Magnetic resonance imaging, Pharmaceuticals application, Cancer Diagnosis, Magnetic Targeting,
Abstract :
Cancer is a fatal disease that has long plagued and damaged people. In the last two decades, many researchers have been interested in the use of magnetic nanoparticles (MNPs) in medicine and pharmaceutical application particularly in the field of cancer diagnostics and treatment. The goal of this article is to provide an overview of MNPs as well as the principles of successful techniques for delivering these nanoparticles to cancer cells. According to an examination, there are two types of active and passive techniques for delivering MNPs to cancer cells. The targeted transfer of nanoparticles to the tumour happens in the active approach, which uses specific molecular ligands of tumour cells and irradiates an external magnetic field to the tumour area, whereas the passive method penetrates the tumour due to its permeability and nanoparticle retention. MNPs offer a variety of applications in biomedicine, including targeted medication delivery to tumours, magnetic resonance imaging, and cancer treatment with hyperthermia, due to their magnetic nature and capacity to carry pharmaceuticals. The use of MNPs in medicine has led to focus on the treatment of cancer. This review indicates that a reduction in the side effects and biological damage produced by chemotherapy in patients can be obtained using MNPs.
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