Utility of Gold Nanoparticles for Spectrofluorimetric and Spectrophotometric Determination of Ceftobiprole in Dosage form and Biological Fluids

Subject Areas : Journal of Nanoanalysis

Hesham Salem ¹ , Mahmoud Omar ² , Dina Zein ³ , Deena Mokhater ⁴

1 - faculty of pharmacy, Deraya university, minia, Egypt
2 - Faculty of pharmacy, Minia University
3 - Faculty of pharmacy, Deraya University
4 - Minia University

Received: 2021-08-27 Accepted : 2022-01-26 Published : 2023-02-15

Keywords: Gold nanoparticles, Spectroscopy, Ceftobiprole, dosage forms, biological fluids,

Abstract :

Two simple, fast and novel delicate fluorimetric and spectrophotometric strategies were examined for the measure of ceftobiprole (CEF) utilizing gold nanoparticles (Au NPs). On spectrofluorimetric strategy, gold nanoparticles were utilized as a fluorescence test. The expansion of CEF to Au-NPs arrangement caused significant quenching of the outflow band of Au-NPs, which was likely due to the complexation of the medicate to gold NPs. Beneath the ideal conditions, the extinguished fluorescence (FL) escalated was straight with the examined concentration. The extinguishing instrument of CEF on the outflow band of Au-NPs was clarified by Stern-Volmer law. The moment spectrophotometric strategy was based on conglomeration of synthesized gold nanoparticles. Gold nanoparticles appeared retention at 522 nm. Upon interaction with the CEF, the band at 522 nm vanished with arrangement of a unused ruddy moved band at 673. Distinctive exploratory variables were optimized for higher affectability. The calibration bands were straight with concentration extend of 0.1-12 µg/mL for the examined medicate. The methods were connected effectively to decide the studiedddrug in minor concentrations in immaculate frame, pharmaceutical measurement shapes and organic liquids (human serum and urine samples).

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