Silica sulfuric acid: an efficient catalyst for the synthesis of substituted indazoles

Subject Areas : Journal of the Iranian Chemical Research

Digambar D. Gaikwad ¹ , Rajendra P. Pawar ²

1 - Department of Chemistry, Govt.College of Arts & Sciences, Aurangabad-4310001, India
2 - Department of Chemistry, Deogiri College, Aurangabad- 431005, India

Received: 2009-12-20 Accepted : 2010-05-30 Published : 2010-12-31

Keywords: Ortho-hydroxy aromatic aldehydes/ketones, Hydrazine hydrate, Silica sulphuric acid,

Abstract :

A simple extremely fast and efficient approach for the synthesis of substituted indazole ingood to excellent yield catalyzed by using silica sulfuric acid (SSA) in DMSO solvent at roomtemperature. This is solid state reaction have been attracting the synthetic organic chemist asthey provided enhance reaction rates, less environmental pollution, greater selectivity, cleanerproducts and manipulative simplicity. Various indazoles are obtained in moderate to excellentyield.

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