Anti-inflammatory and antimicrobial studies of biosensitive Knoevenagel condensate β-ketoanilide Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

Subject Areas : Journal of the Iranian Chemical Research

Natarajan Raman ¹ , Ramaraj Jeyamurugan ² , Jeyasekaran Joseph ³

1 - Research Department of Chemistry, VHNSN College, Virudhunagar-626 001, India
2 - Research Department of Chemistry, VHNSN College, Virudhunagar-626 001, India
3 - Department of Pharmaceutical Chemistry, Manonmanium Sundaranar University, Tirunelveli-627 012, India

Received: 2010-01-10 Accepted : 2010-05-11 Published : 2010-12-31

Keywords: Antimicrobial Activity, Schiff base, Anti-inflammatory activity,

Abstract :

A new series of transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II), has beensynthesized from the Knoevenagel condensate Schiff base ligand(L) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. Structural features were determinedby spectral and analytical techniques. Square-planar geometry has been adopted by thecomplexes except cobalt complex which has an octahedral geometry. The synthesized ligand andits complexes were screened for their anti-inflammatory activity in male albino rats(Carrageenan-induced rat paw oedema model). Among these complexes, copper complex showssignificant anti-inflammatory activity. It exhibits significant dose dependent activity in acuteinflammation. The doses of 100 and 200 mg kg-1 bw produced 38.3 % and 42.8 % inhibitionrespectively after 3 h as compared with that of the standard drug (indomethacin) which showed48.5 % inhibition. The in vitro antimicrobial activity of the ligand and its complexes wasmonitored by disc diffusion method. It has been found that complexes have higher antimicrobialactivity than that of free ligand.

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