Rosa foetida Herrm. flowers as a future natural antibacterial agent against the main cause of skin burn wound infections, Pseudomonas aeroginosa.

Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مائده  رزقی ¹ (گروه داروسازی، دانشکده داروسازی، واحد علوم دارویی، دانشگاه آزاد اسلامی، تهران - ایران (IAUPS))
سید رضا  حسینی دوست ² (گروه میکروبیولوژی، دانشکده داروسازی، واحد علوم دارویی، دانشگاه آزاد اسلامی، تهران - ایران (IAUPS))
ژینوس  عسگرپناه ³ (گروه داروسازی، دانشکده داروسازی، واحد علوم دارویی، دانشگاه آزاد اسلامی، تهران - ایران (IAUPS))

Received: 2014-01-15 Accepted : 2014-04-15 Published : 2015-01-01

Keywords: Antibacterial, Pseudomonas aeruginosa, Rosa foetida, Skin burn wounds,

Abstract :

Background & Aim:Belongs to Rosaecea family, Rosa foetida is one the Persian native plants which has not been investigated biologically. As it is traditionally used topically as poultice to treat infectious skin burns, the present paper focused on the assessment of the antibacterial activities of different extracts of R. foetida flowers against the main cause of skin burn wounds infections, Pseudomonas aeruginosa. Experimental: The antibacterial activity and MIC value determination were investigated by cup plate method and micro plate dilution method respectively. Results: All R. foetid extracts had inhibition activity on the growth of P. aeruginosa of which the aqueous and methanol extracts exhibited the strongest activities. Inhibition zone diameter and MIC values of the concentration of 125 mg/ml of both extracts were found to be somehow the same as those of the standard drug, Imipenem/Cilastatin (8/8 μg/ml). Recommended applications/industries: Results demonstrated that the plant is effective against the standard and pathogenic strains of P. aeruginosa and could be a potential source of effective natural antibacterial compounds to be applied in further phytochemical and invivo biological studies.

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