The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse

Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

فیروزه  سقایی ¹ (گروه علوم پایه، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران)
صادق  معتمدی ² (گروه علوم پایه، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران)

Received: 2016-12-31 Accepted : 2017-04-19 Published : 2017-09-23

Keywords: Anti-inflammatory, Antinociceptive, Satureja bachtiarica, Formalin test, Xylene test,

Abstract :

Background & Aim: The use of anti-nociceptive and anti-inflammatory drugs in clinical medicine is necessary and unavoidable. Since the use of synthetic drugs is associated with numerous side effects, the application of complementary therapies such as herbal medicine can accompany with less side effects while having anti-inflammatory and analgesic properties. Satureja bachtiarica contains different active compounds such as Thymol, Para syman, Menton and Carvacrol which may be involved in the control of nociception and/or inflammation. Experimental: 75 male mice (weighing 30 -20 g) were divided to 15 groups. Analgesic and anti-inflammatory effects of hydroalcoholic Satureja bachtiarica extract at doses of 400, 600, 800 mg/kg were evaluated by writhing, formalin and xylene tests. Morphine (10 mg /kg) and dexamethasone (10 mg/kg) were considered as positive controls in analgesic and anti-inflammatory tests, respectively. Results & Discussion: Different doses of hydroalcoholic extract of Satureja bachtiarica significantly reduced pain in comparison to control groups, however, the anti-inflammatory effect of this drug evaluated by xylene test, has not been established which needs further examination through other tests. Industrial / Practical recommendation: According to present results, the analgesic effect of Satureja bachtiarica was comparable to morphine. However, it seems that further research is needed in the future to take advantage of this plant in relieving pain.

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