Main ingredients in herbal formulation may act as preservative agent
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)
محدثه محبوبی
1
(
گروه میکروبیولوژی، مرکز تحقیقات گیاهان داروئی، کاشان، ایران
)
مریم معمار کرمانی
2
(
گروه میکروبیولوژی، مرکز تحقیقات گیاهان داروئی، کاشان، ایران
)
حسن کرباسی زاده
3
(
گروه فرمولاسیون، مرکز تحقیقات گیاهان دارویی باریج، کاشان، ایران
)
Keywords: Natural preservative, Barij Baby Cream, Antimicrobial effectiveness test,
Abstract :
Background & Aim:Nowadays, the use of chemical preservatives has been limited due to the controversial adverse effects. In this study, we evaluated the preservative potency of product with active herbal ingredients (Barij Baby cream) in contrast with the same products with two different chemical preservatives including methylparaben plus propylparaben and potassium sorbate plus sodium benzoate. Experimental: The efficacy of herbal formulation against pathogens (E. coli, P. aeruginosa, C. albicans, A. niger, S. aureus) was evaluated by antimicrobial effectiveness test during 28 days. Results: 2 log reductions in bacterial counts at 14 days from the initial count, and no growth in bacterial and fungal (molds and yeasts) counts at 28 days from the 14 days is essential for accepting the antimicrobial effectiveness of category 2 products in United States Pharmcopia (USP). Our results of antimicrobial effectiveness test showed that the active herbal ingredients in Barij Baby cream passed the USP criteria as chemical preservatives in the same product. Recommended applications/industries: Therefore, in designing new herbal products, it is essential to evaluate the antimicrobial effectiveness of products before supplemented the product with chemical preservatives.
Darbre, P.D., Aljarrah, A., Miller, W.R., Coldham, N.G., Sauer, M.J. and Pope, G.S. 2004. Concentrations of parabens in human breast tumours. Journal of Applied Toxicology. 24(1): 5-13.
Darbre, P.D. and Harvey, P.W. 2008. Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. Journal of Applied Toxicology. 28(5): 561-578.
de Rapper, S., Kamatou, G., Viljoen, A. and van Vuuren, S. 2013. The in vitro antimicrobial activity of Lavandula angustifolia essential oil in combination with other aroma-therapeutic oils. Evidence-Based Complementary and Alternative Medicine.2013: 1-10
Goudarzi, M., Fazeli, M., Azad, M., Seyedjavadi, S.S. and Mousavi, R. 2015. Aloe vera gel: effective therapeutic agent against multidrug-resistant Pseudomonas aeruginosa isolates recovered from burn wound infections. Chemotherapy Research and Practice.2015: 1-5.
Hashemi, S.A., Madani, S.A. and Abediankenari, S., 2015. The review on properties of Aloe vera in healing of cutaneous wounds. Biomedical Research International. 2015: 1-6.
Herman, A., Herman, A.P., Domagalska, B.W. and Mlynarczyk, A. 2013. Essential oils and herbal extracts as antimicrobial agents in cosmetic emulsion. Indian Journal of Microbiology. 53(2): 232-237.
Ishiwatari, S., Suzuki, T., Hitomi, T., Yoshino, T., Matsukuma, S. and Tsuji, T. 2007. Effects of methyl paraben on skin keratinocytes. Journal of Applied Toxicology. 27(1): 1-9.
Kordsardouei, H., Barzegar, M. and Sahari, M.A. 2013. Application of Zataria multiflora Boiss. and Cinnamon zeylanicum essential oils as two natural preservatives in cake. Avicenna Journal of Phytomedicine. 3(3): 238-247.
Kumar Tyagi, A., Bukvicki, D., Gottardi, D. and Tabanelli, G., Montanari, C., Malik, A., Guerzoni, M.E., 2014. Eucalyptus essential oil as a natural food preservative: in vivo and in vitro antiyeast potential. BioMed Research International. 2014: 1- 9.
Lawrence, R., Tripathi, P. and Jeyakumar, E., 2009. Isolation, purification and evaluation of antibacterial agents from Aloe vera. Brazilian Journal of Microbiology.40(4): 906-915.
Mahboubi, M., Kazempour, N. and Mahboubi, A., 2014. The efficacy of essential oils as natural preservatives in vegetable oil. Journal of Dietary Supplements. 11(4): 334-346.
Panahi, Y., Sharif, M.R., Sharif, A., Beiraghdar, F., Zahiri, Z., Amirchoopani, G., Marzony, E.T. and Sahebkar, A., 2012. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. The Scientific World Journal. 2012:1-5.
Purdel, N.C., Sirbu, A.E. and Nicolescu, F., 2015. Estrogenic burden of parabens used in child care products . Farmacia. 63(1): 118-122.
Routledge, E.J., Parker, J., Odum, J., Ashby, J. and Sumpter, J.P. 1998. Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic. Toxicology and Applied Pharmacology. 153(1):12-19.
Soni, M.G., Burdock, G.A., Taylor, S.L. and Greenberg, N.A. 2001. Safety assessment of propyl paraben: a review of the published literature. Food and Chemical Toxicology 39(6): 513-532.
Srivastava, J.K., Pandey, M. and Gupta, S. 2009. Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life sciences.85(19-20): 663-669.
Surjushe, A., Vasani, R. and Saple, D.G., 2008. Aloe vera: a short review. Indian Journal of dermatology. 53(4): 163-166.
Tavares, R.S., Martins, F.C., Oliveira, P.J., Ramalho-Santos, J. and Peixoto, F.P. 2009. Parabens in male infertility-is there a mitochondrial connection? Reproductive Toxicology. 27(1):1-7.
USP, 2015. Antimicrobial Effectiveness Testing (51), Thirty-Eighth ed. Council of Experts and its Expert Committees. The United States. 1(4):101-103