The effect of Policosanol on decrease of cholesterol, triglyceride and the other lipid metabolite levels in blood of Wistar rats
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)
فاطمه فروهی
1
(
گروه میکروبیولوژی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد شهر قدس، تهران، ایران؛
)
منصور امرایی
2
(
گروه زیست شناسی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد علوم و تحقیقات، تهران، ایران؛
)
هادی زمانی
3
(
گروه زیست شناسی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد شهر قدس، تهران، ایران؛
)
Keywords: Cholesterol, Triglyceride, LDL-C, Policosanal, HDL-C,
Abstract :
Background & Aim: Policosanol is a component from main alcohol groups with long-chain that extracted from cane sugar. In the present research, the effect of policosanol was investigated on decrease of lipid metabolite levels in blood of hypercholesterolemia rats.Experimental: A number of 32 male Wistar rats race with average weight of 250 g was divided into four groups including negative control group (n=8) that had normal diet, positive control and experimental groups I and II (n=8) with high cholesterol diet of 2% cholestroled, and respectively they received placebo and policosanol with concentrations 0.25 and 0.5 mg/day. After four weeks, following the treatment of animals and bloodletting, the biochemical traits such as cholesterol biochemical, triglyceride, and LDL-C and HDL-C factors were measured.Results & Discussion: The results showed that in experimental group (I) there was a significant decrease (p<0.05) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (p<0.05) in HDL-C compared with control group. In experimental group II, there also was a significant decrease (p<0.01) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (p<0.01) in HDL-C compared with control group.Industrial and practical recommendations: Policosanol can be an effective component in decreasing the rate of cholesterol, LDL-C and triglyceride and increasing HDL-C.
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