Black seeds (Nigella sativa) for the management of dengue viral disease: insight into the evidence and POM analyses for the identification of antiviral pharmacophore sites: a review
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)
ناینا محمد پاککر
میدین
1
(فارماکولوژیست، اداره بهداشت دبی، دبی، امارات)
طیبی بن
حدا
2
(دانشگاه ام القری، دانشکده داروسازی، گروه شیمی دارویی، مکه المکرمه، عربستان سعودی;|دانشگاه محمد برتر، دانشکده علوم، آزمایشگاه شیمی کاربردی و محیط زیست، اوجدا، مراکش.)
فیصال
المالکی
3
(دانشگاه ام القری، دانشکده داروسازی، گروه شیمی دارویی، مکه المکرمه، عربستان سعودی;)
حمید
لاروسی
4
(دانشگاه محمد برتر، دانشکده علوم، آزمایشگاه شیمی کاربردی و محیط زیست، اوجدا، مراکش.)
سامه
سلیمان
5
(موسسه تحقیقاتی علوم پزشکی و بهداشت، دانشگاه شارجه، شارجه، امارات متحده عربی؛|کالج داروسازی، دانشگاه شارجه، شارجه، امارات متحده عربی؛)
سارکار
کوثر
6
(آزمایشگاه شیمی کربوهیدرات و نوکلئوزید، گروه شیمی، دانشکده علوم، دانشگاه چیتاگونگ، چیتاگونگ، بنگلادش.)
Keywords: Nigella sativa, Thymoquinone, Black seeds, Dengue virus infection, POM (Petra/Osiris/Molinspiration) theory, Identification of antiviral pharmacophore site,
Abstract :
Background & Aim: The number of dengue virus (DENV) infection cases has increased dramatically over the past two decades, with an estimated 3.9 billion cases across the globe potentially at risk. Patients with a DENV infection are managed symptomatically and by supportive care since there is no approved antiviral drug yet for its management. On the other hand, N. sativa has been highlighted as a potential antiviral, particularly against DENV.Experimental: Hence, the anti-DENV potential of N. sativa is analyzed in this review using major databases, including Medline/PMC/PubMed, Scopus, EBSCO, EMBASE, Google Scholar, and Science Direct. Moreover, the Petra/Osiris/Molinspiration (POM) bioinformatics platform-2019 was used to analyze a series of compounds (1-15) identified in N. sativa (black seeds) to identify those with promising antiviral pharmacophore sites.Results: Preliminary research showed the potential of N. sativa in the control of Aedes aegypti mosquitoes and the enhancement of platelet counts. In addition, several clinical, animal, in vitro and in vivo studies have demonstrated the antiviral, immunomodulatory and anti-inflammatory properties of N. sativa. Furthermore, calculation of the physico-chemical properties of N. sativa compounds using POM analyses indicated that dithymoquinone possesses potential antiviral activity with two (O, O’) pharmacophore sites.Recommended applications/industries: As a result, N. sativa can be employed as an adjuvant/supportive therapy in the management of DENV infection in the early stages of the illness. Furthermore, N. sativa can be a source of new lead anti-DENV drugs.
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