Uses, phytochemistry and biological activity of Piper genus: a review
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)کلمن بادیکو 1 , گدئون بونگو 2 * , کوتو نبولوئا 3 , نادگ نومبی 4 , پائولین کاپپولا 5 , ماری کلاری یاندو 6 , پیوس پیانا 7 , تئوفیل بمبا 8
1 - Department of Biology, Faculty of Sciences, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
|Laboratoire d’Analyse et de Recherche sur l’Alimentation et la Nutrition, Faculté des Sciences, Université de Kinshasa, République Démocratique du Congo (LARAN)
2 - Department of Biology, Faculty of Sciences, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo|Laboratoire d’Analyse et de Recherche sur l’Alimentation et la Nutrition, Faculté des Sciences, Université de Kinshasa, République Démocratique du Congo (LARAN)
3 - Department of Biology, Faculty of Sciences, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
4 - Centre d’Etudes des Substances Naturelles d’Origine Végétale (CESNOV), Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa XI, Democratic Republic of Congo
5 - Centre d’Etudes des Substances Naturelles d’Origine Végétale (CESNOV), Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa XI, Democratic Republic of Congo
6 - Department of Biology, Faculty of Sciences, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo
7 - Department of Chemistry, Faculty of Sciences, University of Kinshasa, P.O.Box 190, Kinshasa XI, Republic of the Congo
8 - Department of Biology, Faculty of Sciences, University of Kinshasa, P.O.Box 190, Kinshasa XI, Democratic Republic of the Congo|Laboratoire d’Analyse et de Recherche sur l’Alimentation et la Nutrition, Faculté des Sciences, Université de Kinshasa, République Démocratique du Congo (LARAN)
Keywords: Biological activity, Uses, Chemical compounds, Piper,
Abstract :
Background & Aim: Piper genus comprises more than 2000 species, mainly found in Asia and Africa. About 40 species are mentioned in the literature and only a small proportion of these species have been studied in depth. The aim of this review is to present data on the traditional uses, biological activities and the chemical composition of different Piper species.Experimental: Several databases like PubMed, PubMed Central, Science Direct, DOAJ, etc.), were used for the search. The term Piper or the scientific names of different species or the combination of terms such as biological activity, phytochemistry and uses with the scientific names or the word "Piper" were used as keywords in the literature search.Results: Species of the Piper genus are of great economic value as they can be used in various sectors such as food, traditional medicine, in the control of certain infectious diseases, crop pest control or in the pharmaceutical industry. Some species are considered a significant source of essential oils. About 400 chemical compounds have been isolated from Piper species, and the alkaloids are the most important group of secondary metabolites; and piperine is the main active alkaloid reported. Moreover, the literature indicates that these species present several biological properties like anti-inflammatory, antioxidant, antibacterial, antifungal, antiplasmodial, analgesic, immunomudatory, antitumour, insecticide, larvicide, amoebicide, antiviral, etc.Recommended applications/industries: The species from Piper genus can be widely used both as a condiment and as medicines to relieve several health problems. However, further studies should be carried out to justify the uses of the less scientifically explored species of Piper genus, and to determine the mechanisms of action or the pharmacokinetics of the active principles already identified and probable synergies between the alkaloids and other chemical groups to evaluate the digestibility and toxicity of extracts from these species.
Ahmad, N., Faza, H., Haider Abbasi, H. B., Farooq, S., Ali, M. and Ali Khan, A. M. 2012. Biological role of Piper nigrum L. (Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine, S1945-S1953.
Amujoyegbe, O. O., Idu, M., Agbedahunsi, J. M. and Erhabor, J. O. 2016. Ethnomedicinal survey of medicinal plants used in the management of sickle cell disorder in Southern Nigeria. Journal of Ethnopharmacology, 185: 347–360.
Angone, A. R. R. R., Aworet, Samseny S. C. and Mve Mba, M. E. 2014. Quelques propriétés des huiles essentielles des plantes médicinales du Gabon. Phytothérapie Lavoisier SAS, 2014: 1-6.
Araujo- Baptista, L. M., Rondón Rivas, M. E., Cruz, Tenempaguay T. R. E., Guayanlema Chávez, G. J. D., Vargas Córdova, C. A. and Morocho Zaragocin, S. V. 2019. Antimicrobial activity of the essential oil of Piper amalago L. (PIPERACEAE) collected in coastal Ecuador. Pharmacologyonline, 3(3): 15-27.
Bastos, M., Houly, R., Conserva, L., Andrade, V., Rocha, E. and Lemos, R. 2011. Antimicrobial and wound healing activities of Piper hayneanum. Journal of Chemical and Pharmaceutical Research, 3: 213-222.
Bekele, D., Petros, B., Tekie, H., and Asfaw, Z. 2014. Larvicidal and adulticidal effects of extracts from some indigenous plants against the malaria vector, Anopheles Arabiensis (Diptera: Culicidae) in Ethiopia. Journal of Biofertilizers and Biopesticides, 5(2): 1-8.
Bezerra, D. P., Pessoa, C., Moraes, M. O. D., Silveira, E. R., Lima, M. A. S., Martins Elmiro, F. J. and Costa-Lotufo, L. V. 2005. Antiproliferative effects of two amides, piperine and piplartine, from Piper species. Zeitschrift für Naturforschung. 60: 539-543.
Bobasa, E. M., Biniyam, G., Alemu, S. T. Shibiru T, Berkessa,, Moti M. Y., Gemechu, Fanta F. G., Fufa, Gemechu G. Z., Cari, W.ote A., Rike. 2018. Antimalarial activity of selected Ethiopian medicinal plants in mice. Journal of Pharmacy and Pharmacognosy Research, 6 (1): 57-64.
Bosquiroli, L. S., Demarque, D. P., Rizk, Y.S., Cunha, M. C., Marques, M. C. S., Maria de Fátima, C. M., Kadri, M. C., Carollo, C. A. and Arruda, C.C. 2015. In vitro anti-leishmania infantum activity of essential oil from Piper angustifolium. Revista Brasileira de Farmacognosia, 25: 124-128.
Calderón, A. I., Romero, L. I., Ortega-Barría, E., Solís, P. N., Zacchino, S., Gimenez, A., Pinzón, R., Cáceres, A., Tamayo, G., Guerra, C., Espinosa, A., Correa, M. and Gupta, M. P. 2010. Screening of Latin American plants for antiparasitic activities against malaria, Chagas disease, and leishmaniasis. Pharmacology and Biology, 48(5): 545-53.
Chahal, J., Ohlyan, R., Kandale, A., Walia, A., Puri, S. 2011. Introduction, phytochemistry, traditional uses and biological activity of genus Piper: A review. International Journal of Current Pharmaceutical Review and Research, 2(2): 130-144.
Choudhary, N. and Singh, V. 2018. A census of P. longum's phytochemicals and their network pharmacological evaluation for identifying novel drug-like molecules against various diseases, with a special focus on neurological disorders. PLoS ONE, 13(1): e0191006.
Conde-Hernández, L. A. and Guerrero-Beltrán, J. Á. Total phenolics and antioxidant activity of Piper auritum and Porophyllum ruderale. Food Chemistry, 142: 455-60.
Cruz, S. M., Cáceres, A., Álvarez, L., Morales, J., Apel, M. A., Henriques, A. T., Salamanca, E., Giménez, A., Vásquez, Y. and Gupta, M. P. 2011. Chemical composition of essential oils of Piper jacquemontianum and Piper variabile from Guatemala and bioactivity of the dichloromethane and methanol extracts. Revista Brasileira de Farmacognosia, 21 (2011): 587-593.
De Feo, V. 2003. Ethnomedical field study in northern Peruvian Andes with particular reference to divination practices. Journal of Ethnopharmacology, 85(2-3): 243–256.
Debebe, E., Dessalegn, T. and, Melaku, Y. 2018. Chemical constituents and antioxidant activities of the fruits extracts of Piper capense. Bulletin of the Chemical Society of Ethiopia, 32(1): 167-174.
Diame, G. L. A. 2010. Ethnobotany and ecological studies of plants used for reproductive health: A case study at Bia biosphere reserve in the western region of Ghana. Final report: Ethnobotany and ecology of plants for reproductive health, University of Cape Coast Ghana. 2010. Pp. 125.
Estevez, Y., Castillo, D., Pisango, M. T., Arevalo, J., Rojas, R., Alban, J., Deharo, E., Bourdy, G. and Sauvain, M. 2007. Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group. Journal of Ethnopharmacology, 114(2): 254-259.
Fankam, A. G., Kuete, V., Voukeng, I. K., Kuiate, J. R. and Pages, J. M. 2011. Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes. BMC Complementary and Alternative Medicine, 11 (104): 1-11.
Ganesh, P., Suresh, Kumar K. R. and, Saranraj, P. 2014. Phytochemical analysis and antibacterial activity of Pepper (Piper nigrum L.) against some human pathogens. Central European Journal of Experimental Biology, 3(2): 36-41.
Garavito, G., Rincón, J., Arteaga, L., Hata, Y., Bourdy, G., Gimenez, A., Pinzón, R. and Deharo, E. 2006. Antimalarial activity of some Colombian medicinal plants. Journal of Ethnopharmacology, 107(3): 460-462.
Gbadamosi, I. T. 2015. An inventory of ethnobotanicals used in the management of sickle cell disease in Oyo State, Nigeria. Botany Research International, 8(4): 65-72.
Gontijo C. D., Alves do Nascimento, M. F., Rody, H. V. S., Magalhães, R. A., Margalho, L. F., Brandão, G. C. and de Oliveira, A. B. 2021. In vitro antiplasmodial activity, targeted LC–MS metabolite profiling, and identification of major natural products in the bioactive extracts of Palicourea and Psychotria species from the Amazonia and Atlantic Forest biomes, Brazil. Metabolomics, 17(9): 81-86.
Hashim, N. A. B. 2018. Phytochemicals and bioactivities of Piper maingayi HK. F., P. magnibaccum C.DC and P. caninum blume species. Doctoral thesis, Universiti Teknologi Malaysia.
Iwu, M. M. 2014. Pharmacognostical profile of selected medicinal plants In: Handbook of African Medicinal Plants CRC Press.
Li, Y., Zhang, J. J., Xu, D. P., Zhou, T., Zhou, Y., Li, S. and Li, H. B. 2016. Bioactivities and Health Benefits of Wild Fruits. International Journal of Molecular Sciences, 17(1258): 1-27.
Lima, C. N. F, Ferreira de Lima, L., Bezerra, Correia C. D., Tavares de Sousa, M.achado S., Pereira de Sousa, J., Soares, Santos S. E., Gyllyandeson, de AraújoA. D., Alencar de Menezes, I. R., Francisco Bezerra, F., Felipe, C., Melo Coutinho, H. D. and Kernto, M. R. 2020. Systematic review: Medicinal use and scientific elucidation of the Piper genus for the treatment of symptoms and inflammatory diseases. Journal of Medicinal Plants Research, 14(2): 62-72.
López, A., Ming, D. S. and Towers, G.N. 2002. Antifungal activity of benzoic acid derivatives from Piper lanceaefolium. Journal of Natural Products, 65: 62-64.
Maryo, M., Nemomissa, S. and Bekele, T. 2015. An ethnobotanical study of medicinal plants of the Kembatta ethnic group in Enset-based agricultural landscape of Kembatta Tembaro (KT) Zone, Southern Ethiopia. Asian Journal of Plant Science and Research, 5(7): 42-61.
Mgbeahuruike, E. E., Yrjönen, T., Vuorela, H., Holm, Y. 2017. Bioactive compounds from medicinal plants: Focus on Piper species. South African Journal of Botany, 112: 54–69.
Ngbolua, K. N., Inkoto, C. L.., Mongo, N. L., Ashande, C. M., YB. Masens, Y. B. and Mpiana, P. T. 2019. Étude ethnobotanique et floristique de quelques plantes médicinales commercialisées à Kinshasa, République Démocratique du Congo. Revue Marocaine des Sciences Agronomiques et Vétérinaires, 7(1): 118-128.
Njeri, L. K., Njagi, E. N. M. 2017. Anti-diabetic activity in mice of Piper Capence used traditionally in the management of diabetes mellitus in Kenya. Journal of Diabetes and Metabolism, 8: 737.
Nkeoua, G. and Boundzanga, G. C. 1999. Données sur les Produits forestiers non ligneux en République du Congo. Projet GCP/INT/679/EC Programme de partenariat – EC – FAO, République du Congo.
Osorio, J. R., Colmenares, Dulcey D. A. J., Mora, E. E., Sánchez, A.ndica R. 2013. Extraction, chemical composition and antimicrobial activity of the essential oils of Pipilongo (Piper tuberculatum) using supercritical carbon dioxide. Exactas Universidad del Valle, Facultad de Ciencias Naturales, 17: 45-56.
Otero, R., Núñez, V., Barona, J., Fonnegra, R., Jiménez, S., Osorio, R., M. Saldarriaga, M. and Dıaz, A. 2000. Snakebites and ethnobotany in the northwest region of Colombia: part III: neutralization of the haemorrhagic effect of Bothrops atrox venom. Journal of Ethnopharmacology, 73: 233-241.
Pandey, P., Singhal, D., Khan, F. and Arif, M. 2021. An in Silico screening on Piper nigrum, Syzygium aromaticum and Zingiber officinale roscoe derived compounds against SARS‐CoV‐2: A drug repurposing approach. Biointerface Research in Applied Chemistry, 11(4): 11122-11134.
Pedersen, M. E., Metzler, B., Stafford, G. I., Van Staden, J., Jäger, A. K. and Rasmussen, H. B. 2009. Amides from Piper capense with CNS Activity –A Preliminary SAR Analysis. Molecules, 14: 3833-3843.
Pereira, F. G., Dias dos Santos, P. R., Guimarães, E. F., Auxiliadora, C. K. M. and Coelho Kaplan M. 2016. Composition of the essential oils from leaves of Piper lepturum Kunth (C.DC.) var. lepturum and Piper lepturum var. angustifolium (Miq.) Yunck. from Brazil. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 15 (2): 88-93.
Priya, N. C. and Saravana Kumari, S. P. 2017. Antiviral activities and cytotoxicity assay of seed extracts of Piper longum and Piper nigrum on human cell lines. International Journal of Pharmaceutical Sciences Review and Research, 41(1): 197-202.
Reshmi, S. K., Suganya, S. and Devi, P. 2010. Isolation of piperdine from Piper nigrum and its antiproliferative activity. Journal of Medicinal Plants Research, 4(15): 1535-1546.
Rusaati, B. I. W., Gendusa, A. P., Joo, S. H., Park, J. W., Masumbuko, N. C., Iragi, K. G., Ngbolua, K. T. N., Furaha, M. A., Rolly, N. K. and, Kang, J. W. 2021. A systematic review of antimalarial medicinal plants in Democratic Republic of the Congo. Bois et Forêts des Tropiques, 347: 11-27.
Salehi, B., Amiruddin, Zakaria Z. Z., Gyawali, R., Salam, Ibrahim I. A., Rajkovic, J., Zabta Shinwari, Z. K., Tariq Khan, T., Sharifi-Rad, J., Ozleyen, A., Turkdonmez, E., Valussi, M., Boyunegmez, Tumer T. T., Monzote, Fidalgo F. L., Martorell, M. and, William Setzer, W. N. 2019. Review piper species: A comprehensive review on their phytochemistry, biological activities and applications. Molecules, 24: 1364-1368.
Salehi, B., Zakaria, Z. A., Gyawali, R., Ibrahim, S. A., Rajkovic, J., Shinwari, Z. K., Khan, T., Sharifi-Rad, J., Ozleyen, A., Turkdonmez, E., Valussi, M., Tumer, T. B., Fidalgo, M. L., Martorell, M. and Setzer, W. N. 2019. Piper species: A comprehensive review on their phytochemistry, biological activities and applications. Molecules, 24(7):1364.
Salleh, W. M. N. H. W., Ahmad, F. and Khong H.K 2014. Chemical composition of Piper stylosum Miq. and piper ribesiodes wall essential oils, and their antioxidant, antimicrobial and tyrosinase inhibition activities. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 13(5): 488-497.
Salleh, W. M. N. W., Athirah Hashim, A. N., Khamis, S. 2019. Chemical constituents and lipoxygenase inhibitory activity of Piper stylosum MIQ. Bulletin of the Chemical Society of Ethiopia, 33(3): 587-592.
Sawadogo, R. W., Schumacher, M., Teiten, M. H. and Diederich, D. M. 2012. Traditional West African pharmacopeia, plants and derived compounds for cancer therapy. Biochemical Pharmacology, 84: 1225–1240.
Seyyedan, A., Yahya, F., Kamarolzaman, M. F. F., Suhaili, Z., Desa, M. N. M., Khairi, H. M., Somchit, M. N., Fatimah, C. A., Teh, L. K., Salleh, M. Z. and Zakaria, Z. A. 2013. Review on the ethnomedicinal, phytochemical and pharmacological properties of Piper sarmentosum: scientific justification of its traditional use. Tang Humanitas Medecine, 3(3): 1-32.
Siddiqui, B. S., Gulzar, T., Mahmood, A., Begum, S., Khan, B., Rasheed, M., Afshan, F., Rajput Tariq, R. M. 2005. Phytochemical studies on the seed extract of Piper nigrum Linn., Natural Product Research: Formerly Natural Product Letters, 19(7): 703-712.
Silva, M. A., da Fialho, S. N., Martinez, L. D. N., Facundo, V. A., da Silva, F. B., Kaplan, M. A. C., Marques, A. M., Bastos, I. D. S., Orlandi, P. P., Pessoa, C. D. Ó, Abreu, B. B. D., Oliveira, F. D. C. E. D., Teles, C. B. G. and Kuehn, C. C. 2020. Chemical composition and biological activities of the leaf extract and essential oil from Piper alatabaccum (Piperaceae) fruits. South American Journal of Basic Education, Technical and Technological, 7(1): 163–185.
Soidrou, S. H., Farah, A., Satrani, B., Ghanmi, M., Lachkar, M. and, Himidi H. A. 2019. Chemical composition, antioxidant and antimicrobial activity of essential oils isolated from two piper species collected in Comoros. International Journal of Pharmacognosy and Phytochemical Research, 11(4): 315-322.
Sonibare, M. A., Moody, J. O. and Adesanya, E. O. 2009. Use of medicinal plants for the treatment of measles in Nigeria. Journal of Ethnopharmacology, 122: 268-272.
Srivastava, A. K. and Kumar Singh, K. V. 2017. Biological action of Piper nigrum - the king of spices. European Journal of Biological Research, 7(3): 223-233.
Stojanovi´c-Radi,´ Z., Pejˇci´, M., Dimitrijevi´, M., Aleksi´c, A., Nanjangud Anil Kumar, N. A. V, Salehi, B., Cho, W. C. and Sharifi-Rad, J. 2019. Piperine- a major principle of black pepper: A review of its bioactivity and studies. Applied Sciences, 9: 4270.
Tang, G. H., Chen, D. M., Qiu, B. Y., Sheng, L., Wang, Y. H., Hu, G. W., Zhao, F. W., Ma, L. J., Wang, H., Huang, Q. Q., Xu, J. J., Long, C. L. and Li, J. 2011. Cytotoxic amide alkaloids from Piper boehmeriaefolium. Journal of Natural Products, 74(1):45-49.
Torres-Pelayo, V. R., Fernandez, M. S., Carmona-Hernandez, O., Molina-Torres, J. and Lozada-Garcia, A. J. 2016. A phytochemical and ethno-pharmacological review of the genus Piper: As a potent bio-insecticide. Research & Reviews. Research Journal of Biology, 4(2): 51104-114.
Traoré, M. C. 2006. Etude de la phytochimie et des activités biologiques de quelques plantes utilisées dans le traitement traditionnel de la dysménorrhée au Mali. Doctoral thesis, University of Bamako. Doctoal dissertation, University of Bamako.
Tsai, I. L., Lee, F. P., Wu, C. C., Duh, C. Y., Ishikawa, T., Chen, J. J., Chen, Y. C., Seki, H., Chen, I. S. 2005. New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens. Planta Medica, 71(6): 535-542.
Umoh, I., Oyebadejo, S., Bassey, E. and Uko, U. 2013. Chronic consumption of Abelmoschus esculentus and Piper guineense induce testicular-toxicity in Wistar rats, histopathological finding. Advances in Life Science and Technology, 14: 98-106.
Valadeau, C., Pabon, A., Deharo, E., Albán-Castillo, J., Estevez, Y., Lores, F. A., Rojas, R., Gamboa, D., Sauvain, M., Castillo, D. and Bourdy, G. 2009. Medicinal plants from the Yanesha (Peru): evaluation of the leishmanicidal and antimalarial activity of selected extracts. Journal of Ethnopharmacology, 123(3): 413-22.
Voukeng, I. K., Kuete, V., Dzoyem, J. P., Fankam, A. G., Noumedem, J. A. K., Kuiate, J. R. and Marie, J. 2012. Antibacterial and antibiotic-potentiation activities of the methanol extract of some Cameroonian spices against Gram-negative multi-drug resistant phenotypes. BMC Research Notes, 5 (299): 1-10.
Wamba, B. E. N., Ghosh, P., Mbaveng, A. T., Bhattacharya, S., Debarpan, M., Depanwita, S., Mitra, Saunak S. M., Kuete, V. and Murmu, N. 2021. Botanical from Piper capense Fruit Can Help to Combat the Melanoma as Demonstrated by In Vitro and In Vivo Studies. Evidence-Based Complementary and Alternative Medicine, 1-15.
Wang, Y. H., Morris‑Natschke, L. S., Yang, J., Niu, H. M., Long, C. L. and Lee, K. H. 2014. Anticancer principles from medicinal Piper Plants. Journal of Traditional and Complementary Medicine, 4(1): 8‑16.
Wansi, J. D., Sewald, N., Nahar, L., Martin, C. and Sarker, S. S. 2019. Bioactive essential oils from the Cameroonian rain forest: A review - Part II. Trends in Phytochemical Research, 3(1): 3-52.
Xiang, C. P., Shib, Y. N., Liub, F. F., Lia, H. Z., Zhang, J. Y., Yang, C. R. and Xua, M. 2016. A survey of the chemical compounds of Piper spp. (Piperaceae) and their biological activities. Natural Product Communications, 11(9): 1403-1408.