Bioactive Glass in Medicine: A Mini-Review of Composition, Properties, Bioactivity Mechanisms, and Clinical Applications

Subject Areas : Journal of Environmental Friendly Materials

S  Mahboubizadeh ¹ (Department of Materials Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.)
P  Noroozi ² (Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran)
O  Ashkani ³ (Department of Materials Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.)

Received: 2023-08-14 Accepted : 2023-12-10 Published : 2023-12-01

Keywords:

Abstract :

From ancient civilizations using gold and silver for healing to the metal surgical instruments of the Renaissance, the introduction of anesthetic and antiseptic treatments in the 19th century, and the 20th century medical device revolution, the history of medical materials is an inventive one. Today, modern healthcare is being shaped by materials like bioglass.Dr. Larry Hench invented bioglass in 1969, and it has since been used extensively in biological and medical application. This brief study covers composition, bioactivity mechanisms, and healthcare applications of bioglass. Bioglass has a wide range of applications, including bone regeneration, tissue engineering, implantable devices, and more thanks to its remarkable bioactivity, biocompatibility, and tissue bonding properties. The sol-gel synthesis method, offering lower processing temperatures and uniform compositions, has gained prominence. Although there are still issues with optimizing bioglass for various biomedical uses, current research and innovation show promise for the material's future advancement in healthcare.

References:

[1] Hench LL. The story of Bioglass®. Journal of Materials Science: Materials in Medicine. 2006 Nov;17(11):967-978.

https://doi.org/10.1007/s10856-006-0432-z

[2] Shahrbabak MS, Sharifianjazi F, Rahban D, Salimi A. A comparative investigation on bioactivity and antibacterial properties of sol-gel derived 58S bioactive glass substituted by Ag and Zn. Silicon. 2019 Dec;11:2741-2751.

https://doi.org/10.1007/s12633-018-0063-2

[3] Alsharabasy AM. A mini-review on the bioactive glass-based composites in soft tissue repair. Bioceram. Dev. Appl. 2018;8(1):8-11.

https://doi.org/10.4172/2090-5025.1000105

[4] Rößler S, Unbehau R, Gemming T, Kruppke B, Wiesmann HP, Hanke T. Calcite incorporated in silica/collagen xerogels mediates calcium release and enhances osteoblast proliferation and differentiation. Scientific Reports. 2020Jan;10(1):118.

https://doi.org/10.1038/s41598-019-56023-8

[5]Anhäuser L, Teders M, Rentmeister A, Glorius F. Bio-additive-based screening: toward evaluation of the biocompatibility of chemical reactions. Nature Protocols. 2019 Sep;14(9):2599-2626. https://doi.org/10.1038/s41596-019-0190-2

[6] Cannio M, Bellucci D, Roether JA, Boccaccini DN, Cannillo V. Bioactive glass applications: A literature review of human clinical trials. Materials. 2021 Sep;14(18):5440.

https://doi.org/10.3390/ma14185440

[7] Daraei J. Production and characterization of PCL (Polycaprolactone) coated TCP/nanoBG composite scaffolds by sponge foam method for orthopedic applications. Journal of Composites and Compounds. 2020 Mar;2(2):44-49.

https://doi.org/10.29252/jcc.2.1.6

[8] Goudarzi Z, Parvin N, Sharifianjazi F. Formation of hydroxyapatite on surface of SiO₂–P₂O₅–CaO–SrO–ZnO bioactive glass synthesized through sol-gel route. Ceramics International. 2019 Oct;45(15):19323-19330.

https://doi.org/10.1016/j.ceramint.2019.06.183

[9] Hoppe A, Güldal NS, Boccaccini AR. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials. 2011 Apr;32(11):2757-2774.

https://doi.org/10.1016/j.biomaterials.2011.01.004

[10] Rahaman MN, Day DE, Bal BS, Fu Q, Jung SB, Bonewald LF, Tomsia AP. Bioactive glass in tissue engineering. Acta biomaterialia. 2011 Jun;7(6):2355-2373. https://doi.org/10.1016/j.actbio.2011.03.016

[11] Frantzén J. BIOACTIVE GLASS IN SPINAL REPAIR. InAn Introduction to Bioceramics 2013 (pp. 159-170).

https://doi.org/10.1142/9781908977168_0012

[12] Dang TH, Bui TH, Guseva EV, Ta AT, Nguyen AT, Hoang TT, Bui XV. Characterization of bioactive glass synthesized by sol-gel process in hot water. Crystals. 2020 Jun;10(6):529. https://doi.org/10.3390/cryst10060529

[13] Ali A, Paladhi A, Hira SK, Singh BN, Pyare R. Bioactive ZnO‐assisted 1393 glass scaffold promotes osteogenic differentiation: Some studies. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2023 May;111(5):1059-1073. https://doi.org/10.1002/jbm.b.35214

[14] Montazerian M, Dutra Zanotto E. History and trends of bioactive glass ceramics. Journal of Biomedical Materials Research Part A. 2016 May;104(5):1231-1249. https://doi.org/10.1002/jbm.a.35639

[15] Vallet-Regí M. Ceramics for medical applications. Journal of the Chemical Society, Dalton Transactions. 2001;2:97-108.

https://doi.org/10.1039/B007852M

[16] Filip DG, Surdu VA, Paduraru AV, Andronescu E. Current Development in Biomaterials—Hydroxyapatite and Bioglass for Applications in Biomedical Field: A Review. Journal of Functional Biomaterials. 2022 Nov 16;13(4):248. https://doi.org/10.3390/jfb13040248

[17] Awaid M, Cacciotti I. Bioactive glasses with antibacterial properties: mechanisms, compositions, and applications. Bioactive Glasses and Glass Ceramics: Fundamentals and Applications. 2022 Aug:581-614.

https://doi.org/10.1002/9781119724193.ch23

[18] Bento R, Gaddam A, Ferreira JM. Sol–gel synthesis and characterization of a quaternary bioglass for bone regeneration and tissue engineering. Materials. 2021 Aug;14(16):4515. https://doi.org/10.3390/ma14164515

[19] Azizabadi N, Azar PA, Tehrani MS, Derakhshi P. Synthesis and characteristics of gel-derived SiO2-CaO-P₂O₅-SrO-Ag₂O-ZnO bioactive glass: Bioactivity, biocompatibility, and antibacterial properties. Journal of Non-Crystalline Solids. 2021 Mar15;556:120568.

https://doi.org/10.1016/j.jnoncrysol.2020.120568

[20] Jones JR. Review of bioactive glass: from Hench to hybrids. Acta biomaterialia. 2013 Jan;9(1):4457-4486. https://doi.org/10.1016/j.actbio.2012.08.023

[21] Deshmukh K, Kovářík T, Křenek T, Docheva D, Stich T, Pola J. Recent advances and future perspectives of sol–gel derived porous bioactive glasses: a review. RSC advances. 2020;10(56):33782-33835.

https://doi.org/10.1039/D0RA04287K

[22] Dash PA, Mohanty S, Nayak SK. A review on bioactive glass, its modifications and applications in healthcare sectors. Journal of Non-Crystalline Solids. 2023 Aug;614:122404.

https://doi.org/10.1016/j.jnoncrysol.2023.122404

[23] Kargozar S, Kermani F, Beidokhti S, Hamzehlou S, VerNe E, Ferraris S, Baini F. Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer. Materials, 2019 Nov;12(22):3696. https://doi.org/10.3390/ma12223696.

[24] Chakraborty PK, Adhikari J, Saha P. Variation of the properties of sol–gel synthesized bioactive glass 45S5 in organic and inorganic acid catalysts. Materials Advances. 2021;2(1):413-425.

https://doi.org/10.1039/D0MA00628A

[25] Dash PA, Mohanty S, Nayak SK. A review on bioactive glass, its modifications and applications in healthcare sectors. Journal of Non-Crystalline Solids. 2023 Aug;614:122404.

https://doi.org/10.1016/j.jnoncrysol.2023.122404

[26] Azizabadi N, Azar PA, Tehrani MS, Derakhshi P. Synthesis and characteristics of gel-derived SiO₂-CaO-P₂O₅-SrO-Ag₂O-ZnO bioactive glass: Bioactivity, biocompatibility, and antibacterial properties. Journal of Non-Crystalline Solids. 2021 Mar;556:120568.

https://doi.org/10.1016/j.jnoncrysol.2020.120568

[27] Fopase RR, Pandey LM, Seal P, Borah JP, Srinivasan A. Assessment of sol-gel derived iron oxide substituted 45S5 bioglass-ceramics for biomedical applications. arXiv preprint arXiv. 2023 Apr;2304.13437.

https://doi.org/10.48550/arXiv.2304.13437

[28] El-Kheshen AA, Khaliafa FA, Saad EA, Elwan RL. Effect of Al2O3 addition on bioactivity, thermal and mechanical properties of some bioactive glasses. Ceramics International. 2008 Sep;34(7):1667-1673. https://doi.org/10.1016/j.ceramint.2007.05.016

[29] Kaur K, Singh KJ, Anand V, Kaur H, Arora DS. In-vitro study of copper doped SiO₂-CaO-P₂O₅ system for bioactivity and antimicrobial properties. InAIP Conference Proceedings 2015 Aug 28 (Vol. 1675, No. 1). AIP Publishing.

https://doi.org/10.1063/1.4929178

[30] Rizwan M, Hamdi M, Basirun WJ. Bioglass® 45S5‐based composites for bone tissue engineering and functional applications. Journal of biomedical materials research Part A. 2017 Nov;105(11):3197-3223. https://doi.org/10.1002/jbm.a.36156

[31] Vallet-Regí M. Ceramics for medical applications. Journal of the Chemical Society, Dalton Transactions. 2001(2):97-108.

https://doi.org/10.1039/B007852M

[32] Kumar A, Murugavel S, Aditya A, Boccaccini AR. Mesoporous 45S5 bioactive glass: Synthesis, in vitro dissolution and biomineralization behavior. Journal of Materials Chemistry B. 2017;5(44):8786-8798. https://doi.org/10.1039/C7TB01738C

[33] Dash PA, Mohanty S, Nayak SK. A review on bioactive glass, its modifications and applications in healthcare sectors. Journal of Non-Crystalline Solids. 2023 Aug;614:122404.

https://doi.org/10.1016/j.jnoncrysol.2023.122404