استفاده از سلول های بنیادی به عنوان رویکرد جدید برای درمان سندرم تخمدان پلی کیستیک

محورهای موضوعی : زیست شناسی سلولی تکوینی گیاهی و جانوری ، تکوین و تمایز ، زیست شناسی میکروارگانیسم

سمیه ابراهیمی باروق ¹ (دانشکده فنآوریهای نوین پزشکی، دانشگاه علوم پزشکی تهران)
فاطمه کوچک زاده ² (علوم پزشکی تهران)
سید مهدی کلانتر ³ (دانشگاه علوم پزشکی شهید صدوقی)
جعفر آی ⁴ (علوم پزشکی تهران)
بهروز افلاطونیان ⁵ (دانشگاه علوم پزشکی شهید صدوقی)

تاریخ دریافت : 1401/10/28 تاریخ پذیرش : 1401/12/19 تاریخ انتشار : 1402/09/01

کلید واژه: درمان, سلول های بنیادی, سندرم تخمدان پلی کیستیک, پزشکی بازساختی,

چکیده مقاله :

سندرم تخمدان پلی کیستیک (PCOS) یک اختلال شایع در زنان است که معمولا در سنین باروری در تعدادی از افراد در سراسر جهان رخ می دهد. علائم شامل اختلال در فولیکولوژنز، هیپرآندروژنیسم، بی نظمی قاعدگی، فولیکول های کیستیک کوچک متعدد، ناباروری و عدم تخمک گذاری مزمن است. مطالعه مروری حاضر با هدف توصیف کاربرد انواع سلول های بنیادی برای درمان سندرم تخمدان پلی کیستیک، ویژگی های بیولوژیکی و مکانیسم اثر آنها انجام شد. در این مقاله نتایج حاصل از مطالعه 53 مقاله از سال 2012 تا 2022 که از پایگاه اطلاعاتی نظیر SID ،Magiran،PubMed ،Google Scholar ،Iranmedx Scopus و clinicaltrials به دست امده بود، جمع آوری گردید. تاکنون سلول های بنیادی مزانشیمی مغز استخوان انسان، بافت چربی انسان، بند ناف انسان و اگزوزوم های مشتق از سلول های بنیادی برای درمان سندرم تخمدان پلی کیستیک در مدل حیوانی و سلول های تخمدان انسانی در مطالعات پیش بالینی استفاده شده است. در حال حاضر تنها دو مطالعه بالینی برای درمان سندرم تخمدان پلی کیستیک با استفاده از سلولهای بنیادی صورت گرفته است. به علت عدم اطمینان از ایمنی این روش به منظور استفاده از سلول های بنیادی در نمونه های انسانی در حال حاضر مطالعات بیشتری در این زمینه باید طراحی و اجرا شود.

چکیده انگلیسی:

Polycystic ovary syndrome (PCOS) is a common disorder in women that usually occurs in reproductive age in a number of people around the world. Symptoms include impaired folliculogenesis, hyperandrogenism, menstrual irregularities, numerous small cystic follicles, infertility, and chronic anovulation. The present review study was conducted with the aim of describing the use of stem cells for the treatment of PCOS, their biological characteristics and mechanism of action. The information related to this review study was collected from 53 papers that searched from databases such as SID, Magiran, PubMed, Google Scholar, Ironed Scopus and clinicaltrials. Currently, only the studies are at the level of pre-clinical studies on bone marrow mesenchymal stem cells, adipose stem cells, cord blood stem cells and exosomes derived mesenchymal stem cells, and there are only two studies on the Clinicaltrials.gov website as clinical studies. Due to the uncertainty of the safety of this method for the purpose of using stem cells in human, more studies in this field should be designed and implemented.

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