Anti-inflammatory and Wound Healing Properties of Curcuma amada and Oregano Essential Oil Derived Hydrogel on 𝘞𝘪𝘴𝘵𝘢𝘳 𝘈𝘭𝘣𝘪𝘯𝘰 Rats

Subject Areas : Journal of Chemical Health Risks

Ramasamy Mahadevi ¹ , Muthugoundar Subramanian Shivakumar ² , Devarajan Natarajan ³ , Singaravel Sengottuvelu ⁴ , Ramamoorthy Kavitha ⁵

1 - Department of Biotechnology, Periyar University, Salem 636011, Tamil Nadu, India
2 - Department of Biotechnology, Periyar University, Salem 636011, Tamil Nadu, India
3 - Department of Biotechnology, Periyar University, Salem 636011, Tamil Nadu, India
4 - Department of Pharmacology, Nandha College of Pharmacy, Erode 638052, Tamil Nadu, India
5 - Department of Biotechnology, Periyar University, Salem 636011, Tamil Nadu, India

Received: 2024-07-02 Accepted : 2024-08-17 Published : 2024-02-15

Keywords: Carbopol 934, Essential oil, Herbal hydrogel, Inflammation, Rhizome, Sodium alginate,

Abstract :

The development of herbal gels for the treating wounds and inflammation is increasing attention to researchers for finding alternatives to conventional drugs with minimal side effects. In the present study, the herbal gel was prepared using Curcuma amada rhizome extract, a combination of oregano oil extracted from Origanum vulgare leaves, and either of three polymers namely carbopol 934, sodium alginate, and sodium carboxymethyl cellulose. Rheological parameters for prepared herbal gel were tested for pH, viscosity, and spreadability. The in-vivo excision wound healing and anti-inflammatory studies were performed on three month-old-male Wistar rats. The results show the best wound healing potential found in herbal formulations containing carbopol 934. This formulation showed good viscosity (65 cPs × 103), spreadability (25 gm × cm sec^-1), in-vitro release (100%) and significant (350.97±0.27 mm²) wound contraction compared to a positive control (neomycin sulfate). The results show the highest anti-inflammatory activity in rats group treated with 200 mg kg^-1 of methanol extract of C.amada compared to control (indomethacin). The gel was prepared using methanol extract of C.amada, oregano oil, and carbopol 934 which are excellent drug candidates for treating wounds and inflammation.

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