Novel Study of the Effect of Spexin Hormone on Heart Attack Disease

Subject Areas : Journal of Chemical Health Risks

Assim Yousif Al- Farag ^{1 *} , Zena A.M. AL-Jawadi ²

1 - Department of Chemistry, College of Science, University of Mosul, Iraq
2 - Department of Chemistry, College of Science, University of Mosul, Iraq

Received: 2024-06-27 Accepted : 2025-05-24 Published : 2025-04-19

Keywords: Spexin Hormone, Heart Attack Disease, Cholesterol, Lipid Profile ,

Abstract :

Spexin hormone (SPX) is a new peptide that has multiple activities in adipose tissue, including energy balance regulation and fatty acid uptakend and related metabolic diseases its physiological significance in the cardiovascular system remains mostly undefined. The aim of the current study was to determine the potential role of Circulating levels of SPX in heart attack illness and potential role in preventing through the measurement spexin hormone, lipid profile, atherogenic risk factor, and body mass index in the serum of 91 heart attack patients and 91 control groups. The age ranges were thirty to seventy-eight, and the study found a substantial drop in spexin hormone and high-density lipoprotein cholesterol levels in comparison with the group in control (P≤0.001). Additionally, all of the following were significantly higher than in the healthy group: body mass index, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, total cholesterol, and atherogenic risk factor at (P≤0.001). The study indicated a substantial relationship between spexin hormone, total cholesterol, and low-density lipoprotein with a high body mass index. As a result, the study proved that a decrease in spexin hormone is a novel indicator of an increase in heart attack disease and has the potential to be employed as an early diagnostic marker in heart attack patients.

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