The Study of the Effect of Alcoholic Extract of Triticum sativum, on the Skin Wound Healing in Diabetic Male Wistar Rats

Subject Areas : Journal of Chemical Health Risks

Asma  Movaghar ¹ (Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran)
Vida  Hojati ² (Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran)
Abdolhossein  Shiravi ³ (Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran)

Received: 2015-07-30 Accepted : 2021-07-24 Published : 2021-10-01

Keywords: Skin, Rat, Diabetes, Wound, Triticum sativum,

Abstract :

Diabetes mellitus is one of the most common diseases in the body’s endocrine system. This disease is caused due to lack of cellular uptake of blood glucose due to a decrease of insulin secretion and insulin resistance in the body cells. Besides the development of diabetes, the more common underlying medical condition, such as foot deformities, foot ulcers, and infection, spreads. Wheat, with the scientific name “Triticum sativum”, is a multiple therapeutic effect, including amplifiers, healer of wounds, stimulating and antiseptic, decreasing blood sugar and pressure, which can be beneficial in balancing sugar and insulin in the blood. Therefore, in this study, the effect of this plant was investigated on skin wound healing in diabetic rats. 48 male rats under the name of Wistar race weighing 200 to 220 grams were categorized into 4 groups and each group has 12 rats in the four categories: control group (without diabetes and treatment), sham (diabetic, treatment with Eucerin), experimental group 1 (diabetic without treatment), and experimental group 2 (diabetic and treatment with Triticum sativum ointment). Some scars were created with a length of 3 cm on the skin of the dorsal lumbar region in the rats of each group, and daily wound healing on these rats was observed. The results indicate that experimental group 2, compared to the rest of the other groups, has the best effect on wound healing. Based on the results of this study, probably, the extract of Triticum sativum, due to anti-steroid and anti-inflammatory attributes, can lead to improvement and decrease the length of the wound in the animal, after 21 days.

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