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Manuscript ID : JCHR-2209-1619 (R2) Visit : 1761 Page: 1 - 10

10.22034/jchr.2023.1967340.1619

Article Type: Original Research

Food Additives, Benefits, and Side Effects: A Review Article

Subject Areas : Journal of Chemical Health Risks

Armineh Lalani 1 , Nima Pouyani 2 , Ali Askari 3 , Shohreh Tavajohi 4 , Sholeh Akbari 5 , Emad Jafarzadeh 6

1 - Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2 - Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3 - Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4 - Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5 - Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
6 - Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Received: 2022-09-09 Accepted : 2023-04-09 Published : 2024-03-01

Keywords: ADHD, immunity, BHA, ulcerative colitis, BHT, Food additives,

Abstract :

Food additivesare substances that have long been applied in processed foods, either natural or synthetic. Several purposes have been fulfilled by the application of food additives, the two most notable of which are known to be preventing food spoilage and providing specific colors and flavors. Some food additives are added to food products through direct contact, whereas the rest are added indirectly e.g., through their packaging bags. In addition to the economic and commercial benefits provided by food additives, over the past two decades, studies have demonstrated a significant correlation between excessive consumption of the foods containing such additives (e.g., BHA and BHT) and several adverse health effects, e.g., the incidence of cancer and skin conditions, among others. Through different age groups, children have been found to be the population at the highest risk for such adverse effects induced by food additives. Indeed, it has been reported that food additives may give rise to attention deficit hyperactivity disorder (ADHD) among the child population. Emerging evidence has shown that emulsifiers (e.g., carboxymethyl cellulose and polysorbate), employed as food additives, might alter gut microbiota composition, leading to ulcerative colitis, affecting immune and inflammatory responses, and mental health problems. Therefore, in this review, alongside the beneficial impact of food additives, their adverse health effects as well as their acceptable daily intake have been investigated.

References:


  1. Pașca C., Coroian A.,Socaci S., 2018. Risks and benefits of food additives-review. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies. 75(2), 71-79.
    2.
  2. Carocho M., Morales P., Ferreira I.C., 2015.Natural food additives: Quo vadis? Trends in Food Science & Technology. 45(2), 284-295.
    3.
  3. Fewtrell L., 2004. Drinking-water nitrate, methemoglobinemia, and global burden of disease: a discussion. Environmental Health Perspectives. 112(14), 1371-1374.
    4.
  4. Pluym N., Burkhardt T., Rögner N., Scherer G., Weber T., Scherer M., Kolossa-Gehring M., 2023. Monitoring the exposure to ethoxyquin between 2000 and 2021 in urine samples from the German Environmental Specimen Bank. Environment International. 172, 107781.
    5.
  5. Shahidi F., Ambigaipalan P., 2015. Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects–A review. Journal of Functional Foods. 18, 820-897.
    6.
  6. Mackay H., Tusabe R., Mugagga F., 2022. Similar, yet different! Comparing Ugandan secondary cities’ food system and nutritional transformations to findings from African primary cities. Urban Transformations. 4(1), 16.
    7.
  7. Ghimire B.K., Yu C.Y., Kim W.R., Moon H.S., Lee J., Kim S.H., Chung I.M., 2023. Assessment of Benefits and Risk of Genetically Modified Plants and Products: Current Controversies and Perspective. Sustainability. 15(2), 1722.
    8.
  8. Eskola M., Kos G., Elliott C.T., Hajšlová J., Mayar S., Krska R., 2020. Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited ‘FAO estimate’of 25%. Critical Reviews in Food Science and Nutrition. 60(16), 2773-2789.
    9.
  9. Tajkarimi M., Ibrahim S.A., Cliver D., 2010.Antimicrobial herb and spice compounds in food. Food Control. 21(9), 1199-1218.
    10.
  10. Carocho M., Barreiro M.F., Morales P., Ferreira I.C., 2014. Adding molecules to food, pros and cons: A review on synthetic and natural food additives. Comprehensive Reviews in Food Science and Food Safety. 13(4), 377-399.
    11.
  11. Simon R.A., 2003. Adverse reactions to food additives. Current Allergy and Asthma Reports. 3(1), 62-66.
    12.
  12. Molognoni L., Daguer H., Motta G.E., Merlo T.C., Lindner J.D.D., 2019. Interactions of preservatives in meat processing: Formation of carcinogenic compounds, analytical methods, and inhibitory agents. Food Research International, 125, 108608.
    13.
  13. Mamur S., Yüzbaşıoğlu D., Ünal F., Aksoy H., 2012. Genotoxicity of food preservative sodium sorbate in human lymphocytes in vitro. Cytotechnology. 64, 553-562.
    14.
  14. Kestenbaum B., Sampson J.N., Rudser K.D., Patterson D.J., Seliger S.L., Young B., Sherrard D.J., Andress D.L., 2005. Serum phosphate levels and mortality risk among people with chronic kidney disease. Journal of the American Society of Nephrology. 16(2), 520-528.
    15.
  15. Billaud C., Roux E., Brun-Merimee S., Maraschin C., Nicolas J., 2003. Inhibitory effect of unheated and heated D-glucose, D-fructose and L-cysteine solutions and Maillard reaction product model systems on polyphenoloxidase from apple. I. Enzymatic browning and enzyme activity inhibition using spectrophotometric and polarographic methods. Food Chemistry. 81(1), 35-50.
    16.
  16. Abbaszadeh S., Sharifzadeh A., Shokri H., Khosravi A., Abbaszadeh A., 2014.Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi. Journal de Mycologie Medicale. 24(2), e51-e56.
    17.
  17. Numpaque M.A., Oviedo L.A., Gil J.H., García C.M., Durango D.L., 2011.Thymol and carvacrol: biotransformation and antifungal activity against the plant pathogenic fungi Colletotrichum acutatum and Botryodiplodia theobromae. Tropical Plant Pathology. 36, 3-13.
    18.
  18. Lahlou R.A., Samba N., Soeiro P., Alves G., Gonçalves A.C., Silva L.R., Silvestre S., Rodilla J., Ismael M.I., 2022. Thymus hirtus Willd. ssp. algeriensis Boiss. and Reut: A Comprehensive Review on Phytochemistry, Bioactivities, and Health-Enhancing Effects. Foods. 11(20), 3195.
    19.
  19. Carocho M., Ferreira I., 2013. Review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food and Chemical Toxicology. 51, 15-25.
    20.
  20. Ferreira I.C., Barros L., Abreu R., 2009.Antioxidants in wild mushrooms. Current Medicinal Chemistry. 16(12), 1543-1560.
    21.
  21. Faustino M.,Veiga M., Sousa P., Costa E.M., Silva S., Pintado M., 2019. Agro-food byproducts as a new source of natural food additives. Molecules. 24(6), 1056.
    22.
  22. Jideani A. I., Silungwe H., Takalani T., Omolola A.O., Udeh H.O., Anyasi T.A., 2021.Antioxidant-rich natural fruit and vegetable products and human health. International Journal of Food Properties. 24(1), 41-67.
    23.
  23. Silva M.M., Reboredo F.H., Lidon F.C., 2022. Food colour additives: A synoptical overview on their chemical properties, applications in food products, and health side effects. Foods. 11(3), 379.
    24.
  24. Xu X., Liu A., Hu S., Ares I., Martínez-Larrañaga M.R., Wang X., Martínez M., Anadón A., Martínez M.A., 2021. Synthetic phenolic antioxidants: Metabolism, hazards and mechanism of action. Food Chemistry. 353, 129488.
    25.
  25. Gharavi N., El-Kadi A.O., 2005. Tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand. Drug Metabolism and Disposition. 33(3), 365-372.
    26.
  26. Silva M.M., Lidon F.C., 2016. An overview on applications and side effects of antioxidant food additives. Emirates Journal of Food and Agriculture. 823-832.
    27.
  27. Jin Y., Guzmán K. E., Boss A.P.,Gangur V., Rockwell C.E., 2023. The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice. Immunopharmacology and Immunotoxicology. 1-7.
    28.
  28. Naczk M., Shahidi F., 2004.Extraction and analysis of phenolics in food. Journal of Chromatography A. 1054(1-2), 95-111.
    29.
  29. Trasande L., 2014. Further limiting bisphenol a in food uses could provide health and economic benefits. Health Affairs. 33(2), 316-323.
    30.
  30. Liu Y., Li A., Buchanan S., Liu W., 2020.Exposure characteristics for congeners, isomers, and enantiomers of perfluoroalkyl substances in mothers and infants. Environment International. 144, 106012.
    31.
  31. Ehrlich S., Williams P.L., Missmer S.A., Flaws J.A., Ye X., Calafat A.M., Petrozza J.C., Wright D., Hauser R., 2012. Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Human Reproduction. 27(12), 3583-3592.
    32.
  32. Cantonwine D.E., Hauser R., Meeker J.D., 2013. Bisphenol A and human reproductive health. Expert Review of Obstetrics & Gynecology. 8(4), 329-335.
    33.
  33. Masuno H., Kidani T., Sekiya K., Sakayama K., Shiosaka T., Yamamoto H., Honda K., 2002. Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes. Journal of Lipid Research. 43(5), 676-684.
    34.
  34. Kim K.Y., Lee E., Kim Y., 2019. The association between bisphenol A exposure and obesity in children—a systematic review with meta-analysis. International Journal of Environmental Research and Public Health. 16(14), 2521.
    35.
  35. Kim J.I., Lee Y.A., Shin C.H., Hong Y.C., Kim B.N., Lim Y.H., 2022.Association of bisphenol A, bisphenol F, and bisphenol S with ADHD symptoms in children. Environment International. 161, 107093.
    36.
  36. Fardous A.M., Beydoun S., James A.A., Ma H., Cabelof D.C., Unnikrishnan A., Heydari A.R., 2022. The timing and duration of folate restriction differentially impacts colon carcinogenesis. Nutrients. 14(1), 16.
    37.
  37. Trasande L., Shaffer R.M., Sathyanarayana S., Lowry J.A., Ahdoot S., Baum C.R., Bernstein A.S., Bole A., Campbell C.C., Landrigan P.J., 2018. Food Additives and Child Health. Pediatrics. 142(2), e20181410.
    38.
  38. Zoeller R., Rovet J., 2004. Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. Journal of Neuroendocrinology. 16(10), 809-818.
    39.
  39. Novais C., Molina A.K., Abreu R.M., Santo-Buelga C., Ferreira I.C., Pereira C., Barros L., 2022.Natural food colorants and preservatives: a review, a demand, and a challenge. Journal of Agricultural and Food Chemistry. 70(9), 2789-2805.
    40.
  40. Dey S., Nagababu B.H., 2022. Applications of food colour and bio-preservatives in the food and its effect on the human health. Food Chemistry Advances. 100019.
    41.
  41. Cao Y., Liu H., Qin N., Ren X., Zhu B., Xia X., 2020. Impact of food additives on the composition and function of gut microbiota: A review. Trends in Food Science & Technology. 99, 295-310.
    42.
  42. Lehmkuhler A., Miller M.D., Bradman A., Castorina R., Chen M.A., Xie T., Mitchell A.E., 2022. Levels of FD&C certified food dyes in foods commonly consumed by children. Journal of Food Composition and Analysis. 112, 104649.
    43.
  43. Stevens L.J., Burgess J.R., Stochelski M.A., Kuczek T., 2014. Amounts of artificial food colors in commonly consumed beverages and potential behavioral implications for consumption in children. Clinical Pediatrics. 53(2), 133-140.
    44.
  44. Nigg J.T., Lewis K., Edinger T., Falk M., 2012. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. Journal of the American Academy of Child & Adolescent Psychiatry. 51(1), 86-97. e88.
    45.
  45. Grosse Y., Baan R., Straif K., Secretan B., El Ghissassi F., Cogliano V., 2006. Carcinogenicity of nitrate, nitrite, and cyanobacterial peptide toxins. The Lancet Oncology. 7(8), 628-629.
    46.
  46. Bouvard V., Loomis D., Guyton K.Z., Grosse Y., El Ghissassi F., Benbrahim-Tallaa L., Guha N., Mattock H., Straif K., 2015. Carcinogenicity of consumption of red and processed meat. The Lancet Oncology. 16(16), 1599-1600.
    47.
  47. Chen Y., Luo Z.C., Zhang T., Fan P., Ma R., Zhang J., Ouyang F., 2023. Maternal thyroid dysfunction and neuropsychological development in children. The Journal of Clinical Endocrinology & Metabolism. 108(2), 339-350.
    48.
  48. Van Asselt E.,Van der Spiegel M., Noordam M., Pikkemaat M., Van der Fels-Klerx H., 2013.Risk ranking of chemical hazards in food—A case study on antibiotics in the Netherlands. Food Research International. 54(2), 1636-1642.
    49.
  49. Walz G., Blazynski N., Frey L., Schneider-Momm K., Clement H.W., Rauh R., Schulz E., Biscaldi M., Clement C., Fleischhaker C., 2022. Long-Term Effects of an Oligoantigenic Diet in Children with Attention-Deficit/Hyperactivity Disorder (ADHD) on Core Symptomatology. Nutrients. 14(23), 5111.
    50.
  50. Wu J., Li P., Luo H., Lu Y., 2022. Complementary and Alternative Medicine Use by ADHD Patients: A Systematic Review. Journal of Attention Disorders. 26(14), 1833-1845.
    51.
  51. Pelsser L.M., Frankena K., Toorman J., Savelkoul H.F., Pereira R.R., Buitelaar J.K., 2009. A randomised controlled trial into the effects of food on ADHD. European Child & Adolescent Psychiatry. 18, 12-19.
    52.
  52. Chassaing B., Koren O., Goodrich J.K., Poole A.C., Srinivasan S., Ley R.E., Gewirtz A.T., 2015. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 519(7541), 92-96.
    53.
  53. Viennois E., Merlin D., Gewirtz A.T., Chassaing B., 2017. Dietary emulsifier–induced low-grade inflammation promotes colon carcinogenesis. Cancer Research. 77(1), 27-40.
    54.
  54. Nickerson K.P., McDonald C., 2012.Crohn's disease-associated adherent-invasive Escherichia coli adhesion is enhanced by exposure to the ubiquitous dietary polysaccharide maltodextrin. PloS one. 7(12), e52132.
    55.
  55. Nickerson K.P., Homer C.R., Kessler S.P., Dixon L.J., Kabi A., Gordon I.O., Johnson E.E., de la Motte C.A., McDonald C., 2014. The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice. PLoS One. 9(7), e101789.
    56.
  56. Campmans-Kuijpers M.J., Dijkstra G., 2021. Food and food groups in inflammatory bowel disease (IBD): The design of the groningen anti-inflammatory diet (GrAID). Nutrients. 13(4), 1067.
    57.
  57. Jafarzadeh E., Shoeibi S., Bahramvand Y., Nasrollahi E., Maghsoudi A.S.,Yazdi F., KarkonShayan S., Hassani S., 2022. Turmeric for Treatment of Irritable Bowel Syndrome: A Systematic Review of Population-Based Evidence. Iranian Journal of Public Health. 51(6), 1223.
    58.
  58. Bian X., Chi L., Gao B., Tu P., Ru H., Lu K., 2017. Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice. Frontiers in Physiology. 8, 487.
    59.
  59. Pinget G., Tan J., Janac B., Kaakoush N.O., Angelatos A.S., O'Sullivan J., Koay Y.C., Sierro F., Davis J., Divakarla S.K., 2019. Impact of the food additive titanium dioxide (E171) on gut microbiota-host interaction. Frontiers in Nutrition. 57. DOI: 10.3389/fnut.2019.00057.

  60. Javurek A.B.,Suresh D., Spollen W.G., Hart M.L., Hansen S.A., Ellersieck M.R., Bivens N.J., Givan S.A., Upendran A., Kannan R., 2017. Gut dysbiosis and neurobehavioral alterations in rats exposed to silver nanoparticles. Scientific Reports. 7(1), 1-15.
    61.
  61. Holder M.K., Peters N.V., Whylings J., Fields C.T., Gewirtz A.T., Chassaing B., de Vries G.J., 2019. Dietary emulsifiers consumption alters anxiety-like and social-related behaviors in mice in a sex-dependent manner. Scientific Reports. 9(1), 1-14.
    62.
  62. Alizadeh A., Moradi M., Irannejad V.S., 2023. Effects of Postbiotics from Food Probiotic and Protective Cultures on Proliferation and Apoptosis in HCT-116 Colorectal Cancer Cells. Applied Food Biotechnology. 10(2), 85-101.
    63.

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