Evaluation of Blood Components of Glycemic Control in Diabetics with and without Cataract in Comparison with Non-diabetics

Subject Areas : Journal of Chemical Health Risks

Elham Zainalinia ¹ , Rouhallah Najjar Sadeghi ² , Mostafa Ebadi ³ , Mohammad Faghihi ⁴

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Clinical Biochemistry, faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
4 - Department of Medical Sciences of Shahid Beheshti University, Surgeon and Ophthalmologist of Tehran, Iran

Received: 2022-02-25 Accepted : 2023-01-29 Published : 2023-12-01

Keywords: Diabetes, Cataract, OGTT, Fasting Plasma Glucose, Hemoglobin A1c,

Abstract :

Cataract is a leading cause of vision loss in the world. Several factors are involved in the development of cataracts, of them; diabetes and uncontrolled plasma glucose have great importance. Therefore, controlling glycemic reduces the risk of related to microvascular complications of diabetes diseases such as cataract. This study aimed to compare fasting plasma glucose (FPG), HgbA1c, and oral glucose tolerance test (OGTT) between Diabetic patients with and without cataract in comparison with the healthy group as control. Among 150 subjects, 50 diabetic patients, 50 diabetic cataracts, and 50 healthy individuals without a history of specific disease were compared with each other. Fasting plasma glucose, OGTT, and HgbA1c were measured by colorimetric methods. SPSS23 software was used to analyze data. P-values ​​less than 5% or lower were considered to be statistically significant. In this study, the mean fasting plasma glucose, HgbA1c, and OGTT in the group of diabetic patients, diabetic with cataract, and healthy groups fasting plasma glucose were as follow, 162.46 mg dL-1 and 184.76 mg dL-1, 92.88 mg dL-1 (P˂0.05), HgbA1c: 7.8, 8.0, 5.8% (P˂0.05) and OGTT: 228 mg dL-1, 246.12 mg dL-1 and 114.32 mg dL-1 (P˂0.05) respectively. Our findings showed that in diabetic patients with and without cataract, fasting plasma levels, HgbA1C, and OGTT are higher than the healthy group. There was a significant relationship between the studied factors and cataracts. As a result, high blood glucose has a definitive role in the development of cataracts.

References:

1. Ao M., Li X., Qiu W., Hou Z., Su J.,Wang W., 2019. The impact of age-related cataracts on colour perception, postoperative recovery and related spectra derived from test of hue perception. BMC Ophthalmol.19(1), 56.


2. Kitamura A., Taniguchi Y., Seino S., Yokoyama Y., Amano H., Fujiwara Y.,Shinkai S., 2019. Combined effect of diabetes and frailty on mortality and incident disability in older Japanese adults. Geriatr Gerontol Int.19(5), 423-428.


3. Al-Lawati J.A., 2017. Diabetes Mellitus: A Local and Global Public Health Emergency! Oman Med J. 32(3), 177-179.


4. Guariguata L., Whiting D.R., Hambleton I., Beagley J., Linnenkamp U.,Shaw J.E., 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract.103(2), 137-149.


5. Javanbakht M., Mashayekhi A., Baradaran H.R., Haghdoost A., Afshin A., 2015. Projection of Diabetes Population Size and Associated Economic Burden through 2030 in Iran: Evidence from Micro-Simulation Markov Model and Bayesian Meta-Analysis. PLoS One.10(7), e0132505.


6. Posner B.I., 2017. Insulin Signalling: The Inside Story. Can J Diabetes.41(1), 108-113.


7. Maseko S.N., van Staden D.,Mhlongo E.M., 2021. The Rising Burden of Diabetes-Related Blindness: A Case for Integration of Primary Eye Care into Primary Health Care in Eswatini. Healthcare. 9(7), 835.


8. Chehregosha H., Khamseh M.E., Malek M., Hosseinpanah F.,Ismail-Beigi F., 2019. A View Beyond HbA1c: Role of Continuous Glucose Monitoring. Diabetes Ther. 10(3), 853-863.


9. Deshpande A.D., Harris-Hayes M., Schootman M., 2008. Epidemiology of diabetes and diabetes-related complications. Phys Ther. 88(11), 1254-64.


10. Tanya S.M., Nguyen A.X., Pur D.R., Nguyen M., Kherani F., Costello F., Kohly R., 2022. Bridging gaps in access to ophthalmology mentorship with the virtual Canadian Ophthalmology Mentorship Program. Eye (Lond). 36(9):1848-1849. doi: 10.1038/s41433-021-01899-y


11. Lee C.M.,Afshari N.A., 2017. The global state of cataract blindness. Curr Opin Ophthalmol. 28(1), 98-103.


12. Drinkwater J.J., Davis W.A.,Davis T.M., 2019. A systematic review of risk factors for cataract in type 2 diabetes. Diabetes Metab Res Rev. 35(1), e3073.


13. Kiziltoprak H., Tekin K., Inanc M.,Goker Y.S., 2019. Cataract in diabetes mellitus. World J Diabetes.10(3), 140-153.


14. Becker C., Schneider C., Aballéa S., Bailey C., Bourne R., Jick S., Meier C., 2018. Cataract in patients with diabetes mellitus—incidence rates in the UK and risk factors. Eye. 32(6), 1028-1035.


15. Singh S., Pardhan S., Kulothungan V., Swaminathan G., Ravichandran J.S., Ganesan S., Sharma T., Raman R., 2019. The prevalence and risk factors for cataract in rural and urban India. Indian J Ophthalmol.67(4), 477-483.


16. Tan A. G., Kifley A., Holliday E.G., Klein B.E.K., Iyengar S.K., Lee K.E., Jun G.R., Cumming R.G., Zhao W., Wong T.Y., Cheng C.Y., Mitchell P.,Wang J.J., 2018. Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract. Invest Ophthalmol Vis Sci. 59(11), 4755-4762.


17. Sharma S., Chataway T., Klebe S., Griggs K., Martin S., Chegeni N., Dave A., Zhou T., Ronci M., Voelcker N.H., Mills R.A., Craig J.E., 2018. Novel protein constituents of pathological ocular pseudoexfoliation syndrome deposits identified with mass spectrometry. Mol Vis. 24, 801-817.


18. Ekström C.,Grunditz Ustrup J., 2021. Association between Age-related Cataract and Mortality in Sweden: A Long-term Population-based Follow-up Study. Ophthalmic Epidemiol. 28(4), 301-305.


19. Chen X., Ye G., Zhong Y., Jin L., Liang X., Zeng Y., Zheng Y., Lan M., Liu Y., 2021. Prevalence, incidence, and risk factors for myopia among urban and rural children in southern China: protocol for a school-based cohort study. BMJ Open.11(11), e049846.