Supplemental Effect of Zinc Oxide Nanoparticles and Prangos ferulacea Butanol Extract on Blood Glucose of Diabetic Wistar Rats

Subject Areas : Journal of Chemical Health Risks

Hamid Dadar ¹ (Deptartment of Biochemistry, Shiraz Branch, Islamic Azad University, Shiraz, Iran)
Reza Bzorgyan ² (Deptartment of Microbiology, Shiraz Branch, Islamic Azad University Shiraz, Iran)
Freshteh Rahdan ³ (Deptartment of Biotechnology, Dehdasht Branch, Islamic Azad University, Dehdasht, Iran)
Elahe Piraei ⁴ (Deptartment of Biotechnology, Dehdasht Branch, Islamic Azad University, Dehdasht, Iran)
Yadollah Edalatpanah ⁵ (Deptartment of Biochemistry, Dehdasht Branch, Islamic Azad University, Dehdasht, Iran)

Received: 2017-04-26 Accepted : 2018-10-29 Published : 2017-04-26

Keywords: glucose, Diabetes mellitus, Rats, Prangos ferulacea, Zinc oxide nanoparti-cles,

Abstract :

Diabetes mellitus is one of the most common diseases affecting the endocrine system. The prevalence of diabetes mellitus will be increasing in the human population. It is a metabolic disease characterized by chronic escalation of blood glucose and disrupted metabolism of carbohydrates, fats and proteins. This was an experimental study conducted on 40 male Wistar rats. This study was carried out in 2015 at the Islamic Azad University of Dehdasht. Diabetes was induced in the animals through Streptozotocin (STZ). After three days, blood glucose levels were measured. The rats were diagnosed with diabetes when blood glucose was more than 250. The data were analyzed through SPSS 21. Moreover, the independent t-test was used to examine the relationship between variables. Results of statistical analysis in relation to body weight of rats showed that there was a significant relationship between all groups at P<0.05 except for diabetic group and diabetic group by Prangos ferulacea Butanol extract as well as diabetic group by P. ferulacea butanol extract and diabetic groups by P. ferulacea butanol extract and zinc oxide nanoparticles. Concerning the glucose levels, there was a significant relationship between all groups at P<0.05. When applied as a supplement, zinc oxide nanoparticles and P. ferulacea butanol extract can have anti-diabetic properties, curtailing blood glucose, revealing that nanoparticles can be used in the future as a treatment for diabetes.

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