Nutraceutical Potential of Tetracarpidium conophorum and Buccholzia coriacea in Diet-induced Hyperlipidemia

Subject Areas : Journal of Chemical Health Risks

Eucharia Oluchi Nwaichi ¹ , Justice Obinna Osuoha ² , Michael Okechukwu Monanu ³

1 - Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria, 23400
2 - Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria, 23400
3 - Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria, 23400

Received: 2017-09-03 Accepted : 2018-10-29 Published : 2017-09-03

Keywords: Medicinal Plants, Lipid profile, Hepatotoxicity, Hyperlipidemia, Atherogenic indices, Marker enzymes,

Abstract :

The nutraceutical potential of Tetracarpidium conophorum and Buccholzia coriacea in diet-induced hyperlipidemia in male Wistar rats were investigated at the Plant Science and Biotechnology department, University of Port Harcourt, Nigeria in 2016. Diet-induced type II A hyperlipidemia in rat model was achieved by oral administration of egg yolk and groundnut oil formulations for 2 wk. Rats fed with normal diet and diet formulations constituted the negative control and test control in that order for comparison. The hyperlipidemic rats were subsequently treated with normal feed supplemented with 500 mgkg-1 and 1000 mgkg-1 of T. conophorum and B. coriacea for two weeks. In comparison to test control animals, administration of tried samples markedly lowered weight gain by experimental animals, total cholesterol, triglycerides, AST, ALT ALP, plasma contents of LDL, VLDL, Non-HDL and atherogenic indices in a dose- dependent fashion. Their administration also produced significantly higher (P<0.05) plasma HDL cholesterol levels indicating recovery. These findings underscore the nutraceutical potentials of T. conophorum and B. coriaceaand suggest their possible use in management of hyperlipidemia and other related diseases.

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