اثر محافظتی نانوکورکومین بر آسیب بافتی کلیوی در مسمومیت ناشی از سالینومایسین جوجه های گوشتی
محورهای موضوعی : پاتولوژی
سید محمد حسینی
1
(بخش پاتولوژی، دانشکده دامپزشکی، واحد بابل ، دانشگاه آزاد اسلامی، بابل ، ایران)
رضا صیرفی
2
(بخش علوم پایه، دانشکده دامپزشکی، دانشگاه تخصصی فناوری های نوین آمل، آمل ، ایران)
صابر یوسفی رباطی
3
(بخش پاتولوژی، دانشکده دامپزشکی، واحد بابل ، دانشگاه آزاد اسلامی، بابل ، ایران)
ابوالفضل اکبری
4
(بخش فیزیولوژی ، دانشکده دامپزشکی، دانشگاه شیراز، شیراز، ایران ; بخش فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران )
علیرضا صالحی
5
(بخش پاتولوژی، دانشکده دامپزشکی، واحد بابل ، دانشگاه آزاد اسلامی، بابل ، ایران)
کلید واژه: نانوکورکومین, سالینومایسین, کلیه, آنتی اکسیدان, جوجه گوشتی,
چکیده مقاله :
سالینومایسین یک آنتی بیوتیک یونوفوره بوده که به طور گسترده در صنعت طیور برای کنترل و پیشگیری از کوکسیدیوز استفاده می شود. سمیت یونوفور احتمالاً به دلیل آسیب اکسیداتیو ناشی از تولید رادیکال های آزاد است. کورکومین جزء اصلی زردچوبه بوده که دارای طیف وسیعی از فعالیت آنتی اکسیدانی، ضد التهابی و ضد سرطانی است. هدف از این مطالعه بررسی اثر نانو کورکومین به عنوان یک آنتی اکسیدان طبیعی بر جوجه های گوشتی مسموم شده با دوز سمی سالینومایسین بود. در این مطالعه 60 قطعه جوجه گوشتی به طور تصادفی به 5 گروه تقسیم شدند. گروه اول به عنوان شاهد در نظر گرفته شد. گروه دوم سالینومایسین را با دوز 300 میلی گرم بر کیلوگرم وزن بدن، روزانه به مدت 14 روز دریافت کردند. گروه های 3، 4 و 5 علاوه بر سالینومایسین، به ترتیب روزانه 50، 100 و 200 میلی گرم بر کیلوگرم وزن بدن نانوکورکومین را به مدت 14 روز دریافت کردند. سپس، نمونه های خون و بافت برای ارزیابی بیوشیمیایی و هیستوپاتولوژی جمع آوری شد. مشاهده شد که نانوکورکومین بروز و شدت ضایعات هیستوپاتولوژیک کلیه را کاهش داده و به نظر می رسد که درمان با نانوکورکومین باعث بهبود وضعیت و کاهش تعداد سلول های التهابی می شود. همچنین پارامترهای هیستومورفومتری را به طور معنی داری بهبود بخشید (05/0>p). به نظر می رسد شرایط نامطلوب ناشی از مسمومیت با سالینومایسین با تجویز خوراکی نانوکورکومین قابل بهبود باشد.
Salinomycin (SLM) is an ionophore antibiotic used extensively in the poultry industry for the control and prevention of coccidiosis. The toxicity of the ionophore is thought to be due to oxidative damage caused by the production of free radicals. Curcumin is a major component of turmeric, which has a wide range of antioxidant, anti-inflammatory and anticancer activities. The aim of this study was to evaluate the effect of nanocurcumin (NC) as a natural antioxidant on broiler chickens poisoned with a toxic dose of SLM. In this study, 60 broilers were randomly divided into 5 groups. The first group was considered as control. The second group received SLM at a dose of 300 mg/kg bw per day for 14 days. Groups 3, 4 and 5 received oral doses of NC at 50, 100 and 200 mg/kg bw per day for 14 days in addition to SLM. After 14 days, blood and kidney tissue samples were collected for biochemical and histopathological evaluation. It was observed that NC reduced the incidence and severity of renal histopathological lesions. The highest levels of inflammatory cells were observed in the cortex and medulla of the SLM group and it appeared that treatment with NC improved the condition and reduced the presence of inflammatory cells. It also significantly improved renal histomorphometric parameters (P<0.05). It seemed that SLM-induced adverse conditions can be reversed by oral administration of NC.
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