بررسی خواص بیولوژیک پسته Pistacia vera به عنوان محبوبترین آجیل غذایی
محورهای موضوعی : علوم و صنایع غذاییشهاب اوجانی 1 , مژگان مسعودی 2
1 - گروه شیمی، واحد رفسنجان، دانشگاه آزاد اسلامی، رفسنجان، ایران.
2 - گروه شیمی، واحد رفسنجان، دانشگاه آزاد اسلامی، رفسنجان، ایران.
کلید واژه: آنتیاکسیدان, ترکیبات فیتوشیمیایی, رادیکالهای آزاد, Pistacia vera.,
چکیده مقاله :
از زمان کشف این که رادیکالهای آزاد نقش مهمی را در ایجاد بیماریهایی مانند سرطان، دیابت، آلزایمر، بیماری های قلبی - عروقی و غیره ایفا میکنند، استفاده از آنتیاکسیدانهای طبیعی در زنجیره غذایی برای داشتن یک سبک زندگی سال بسیار تاکید شده است. در این میان، پسته یکی از محبوبترین آجیلهای غذایی در جهان می باشد که حاوی ترکیبات فیتوشیمیایی غنی با خواص آنتیاکسیدانی است. پسته بو داده ایرانی و آمریکایی به دلیل داشتن شکل مناسب و با وجود طعم دلپذیر و منحصر به فرد، به عنوان گزینه ای مناسب برای دسرهای مختلف (حلوا، کیک، بستنی و غیره) استفاده می شوند و در کنار داشتن خواص بی نظیر مورد استقبال مصرفکنندگان قرار میگیرد که تاثیر بسزایی بر سلامت انسان به ویژه بر سیستم قلبی - عروقی دارد. طبق تحقیقات انجام شده پروتئین میوههای خشک مانند پسته حاوی اسیدآمینه آرژنین است که پیش ساز نیتریک اکسید می باشد و نیتریک اکسید نیز مسئول تنظیم فشار خون و جلوگیری از انسداد رگهای خونی است. ترکیبات فیتوشیمیایی پسته شامل فنولیک اسیدها، فلاونوئیدها، تاننها، کومارینها، لیگنانها، کینونها، آنتوسیانین و غیره است و به دلیل وجود این ترکیبات زیست فعال اثرات سمیت سلولی قابل ملاحظه ای را در برابر سلول های سرطان روده بزرگ HT29 ، سلول های سرطان پستان T47D، سلول های سرطان HepG2 و غیره از خود نشان می دهد. از این رو، در پژوهش حاضر به بررسی خواص بیولوژیک پسته Pistacia vera به عنوان محبوبترین آجیل غذایی پرداخته می شود.
Today, there is a lot of emphasis placed on the use of natural antioxidants in the food chain to have a healthy lifestyle due to the discovery that free radicals play an important role in causing diseases such as cancer, diabetes, Alzheimer's, cardiovascular diseases, etc. Meanwhile, Pistacia vera is considered as one of the most popular food nuts in the world, which contains rich phytochemical compounds with antioxidant properties. Iranian and American roasted Pistacia vera are used as a suitable flavoring for various desserts (halva, cake, ice cream, etc.) and it is welcomed by consumers, besides having unique properties that have a significant impact on human health, especially on the cardiovascular system. According to the results of the research, the protein of dried fruits like Pistacia vera contains amino acid arginine, which is a precursor of nitric oxide, and nitric oxide is also responsible for regulating blood pressure and preventing blockage of blood vessels. Phytochemical compounds of Pistacia vera include phenolic acids, flavonoids, tannins, coumarins, lignans, quinones, anthocyanins, etc., and due to the presence of these bioactive compounds, they have significant cytotoxic effects against HT29 colon cancer cells, T47D breast cancer cells, HepG2 cancer cells, etc. Therefore, this study examines the biological properties of Pistacia vera as the most popular nut.
1. AL-Saghir, M.G. and Porter, D.M. 2012. Taxonomic revision of the genus Pistacia L. (Anacardiaceae). American journal of plant sciences, 3(1): p. 12.
2. Arcan, I. and Yemenicioğlu, A. 2009. Antioxidant activity and phenolic content of fresh and dry nuts with or without the seed coat. Journal of food composition and analysis, 22(3): 184-188.
3. Azadedel, S. Hanachi, P. and Saboora, A. 2018. Investigation on antioxidant activity of pistachio (Pistacia vera L.) skin extraction. Journal of plant research (Iranian journal of biology), 30(4): 722-731.
4. Anu, K. Devanesan, S. Prasanth, R. AlSalhi, M.S. Ajithkumar, S. and Singaravelu, G. 2020. Biogenesis of selenium nanoparticles and their anti-leukemia activity. Journal of king saud university-science, 32(4): 2520-2526.
5. Bachrouch, O. Jemâa, J.M.B. Wissem, A.W. Talou, T. Marzouk, B. and Abderraba, M. 2010. Composition and insecticidal activity of essential oil from Pistacia lentiscus L. against Ectomyelois ceratoniae Zeller and Ephestia kuehniella Zeller (Lepidoptera: Pyralidae). Journal of stored products research, 46(4): 242-247.
6. Barreca, D. Laganà, G. Leuzzi, U. Smeriglio, A. Trombetta, D. and Bellocco, E. 2016. Evaluation of the nutraceutical, antioxidant and cytoprotective properties of ripe pistachio (Pistacia vera L., variety Bronte) hulls. Food chemistry, 196: 493-502.
7. Balan, K.V. Prince, J. Han, Z. Dimas, K. Cladaras, M. Wyche, J.H. Sitaras, N.M. and Pantazis, P. 2007. Anti-proliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia. Phytomedicine, 14(4): 263-272.
8. Benhammou, N. Bekkara, F.A. and Panovska, T.K. 2008. Antioxidant and antimicrobial activities of the Pistacia lentiscus and Pistacia atlantica extracts. African journal of pharmacy and pharmacology, 2(2): 022-028.
9. Bhunia, A.K. 2008. Bacillus cereus and Bacillus anthracis. Foodborne microbial pathogens: Mechanisms and pathogenesis, 135-148.
10. Blois, M.S. 1958. Antioxidant determinations by the use of a stable free radical. Nature, 181(4617): 1199-1200.
11. Brand-Williams, W. Cuvelier, M.E. and Berset, C.L.W.T. 1995. Use of a free radical method to evaluate antioxidant activity. LWT-Food science and technology, 28(1): 25-30.
12. Chang, C.C. Yang, M.H. Wen, H.M. and Chern, J.C. 2002. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. Journal of food and drug analysis, 10(3).
13. Cushnie, T.T. and Lamb, A.J. 2005. Antimicrobial activity of flavonoids. International journal of antimicrobial agents, 26(5): 343-356.
14. Dahooee, F. Fatemi, S.J. Mandegary, A. and Sharififar, F. 2016. Iron chelating and antioxidant activities and cytotoxicity effect of the Pistachio (Pistachio vera L.) hull and kernel extracts in the A549, HT29 and MCF-7 cancerous cell lines. International journal of clinical pharmacology & toxicology, 5(1): 195-201.
15. Dragull, K. Beck, J.J. and Merrill, G.B. 2010. Essential oil yield and composition of Pistacia vera ‘Kerman’fruits, peduncles and leaves grown in California. Journal of the Science of Food and Agriculture, 90(4): 664-668.
16. Ellis, M.J. 1994. The methodology of shelf life determination. In Shelf life evaluation of foods. Boston, MA: Springer US, 27-39.
17. Ezatpour, B. Saedi Dezaki, E. Mahmoudvand, H. Azadpour, M. and Ezzatkhah, F. 2015. In vitro and in vivo antileishmanial effects of Pistacia khinjuk against Leishmania tropica and Leishmania major. Evidence based complementary and alternative nedicine, 2015(1): 149707.
18. Falahati-pour, S.K. Khoradmehr, A. Baghery, F. Amin, F. Parvaz, N. and Pourmasumi, S. 2024. Antioxidant properties of Pistacia vera against the effects of phenylhydrazine induced hemolytic anemia on male fertility in mice. Andrologia, 2024(1): 5512743.
19. Fernández-Agulló, A. Pereira, E. Freire, M.S. Valentão, P. Andrade, P.B. González-Álvarez, J. and Pereira, J.A. 2013. Influence of solvent on the antioxidant and antimicrobial properties of walnut (Juglans regia L.) green husk extracts. Industrial crops and products, 42: 126-132.
20. Garcia, J.M. Agar I.T. and Streif J. 1992. Fat content and fatty acid composition in individual seeds of Pistachio varieties grown in Turkey. European journal of horticultural science. 57(3): 130-133.
21. Gheysarbigi, S. Mirdehghan, S.H. Ghasemnezhad, M. and Nazoori, F. 2020. The inhibitory effect of nitric oxide on enzymatic browning reactions of in-package fresh pistachios (Pistacia vera L.). Postharvest biology and technology, 159: 110998. https://ma.x-mol.com/paperRedirect/5880 064.
22. Giner-Larza, E.M. Máñez, S. Recio, M.C. Giner, R.M. Prieto, J.M. Cerdá-Nicolás, M. and Rı́os, J.L. 2001. Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. European journal of pharmacology, 428(1): 137-143.
23. Goli, A.H. Barzegar, M. and Sahari, M.A. 2005. Antioxidant activity and total phenolic compounds of pistachio (Pistachia vera) hull extracts. Food chemistry, 92(3): 521-525.
24. Hanachi, P. and Azadedel, S. 2022. Investigation of antibacterial properties in Pistacia vera L. extract on Staphylococcus aureus. Navid No, 25(81): 57-66.
25. Hanachi, P. and Saboora, O. 2016. Investigation of soluble and insoluble tannins and anthocyanins assay in two Cultivar pistachio (Pistacia vera L). Journal of food science and technology (Iran), 14(63): 179-186.
26. Hojjati, M. Calín‐Sánchez, Á. Razavi, S.H. and Carbonell‐Barrachina, Á.A. 2013. Effect of roasting on color and volatile composition of pistachios (Pistacia vera L.). International journal of food science & technology, 48(2): 437-443.
27. Hoerger, T.J. Bala, M.V. Bray, J.W. Wilcosky, T.C. and LaRosa, J. 1998. Treatment patterns and distribution of low-density lipoprotein cholesterol levels in treatment-eligible United States adults. The American journal of cardiology, 82(1): 61-65.
28. Hosseinzadeh, H. Behravan, E. and Soleimani, M.M. 2011. Anti-nociceptive and anti-inflammatory effects of Pistacia vera leaf extract in mice. Iranian journal of pharmaceutical research: IJPR, 10(4): p. 821.
29. Hosseinzadeh, H. Tabassi, S.A.S. Moghadam, N.M. Rashedinia, M. and Mehri, S. 2012. Antioxidant activity of Pistacia vera fruits, leaves and gum extracts. Iranian journal of pharmaceutical research, 11(3): p. 879.
30. Iranmanesh, F. Amin, A.M. Shamsizadeh, A. Fatemi, I. Rad, A.M. and Rahnama, A. 2017. Effects of Pistacia vera hydro-alcoholic extract on carbon tetrachloride-induced hepatotoxicity in male rats. Iranian journal of pharmacology & therapeutics, 14(2): 35-40.
31. Kashaninejad, M. Mortazavi, A. Safekordi, A. and Tabil, L.G. 2006. Some physical properties of Pistachio (Pistacia vera L.) nut and its kernel. Journal of food engineering, 72(1): 30-38.
32. Kawashty, S.A. Mosharrafa, S.A.M. El-Gibali, M. and Saleh, N.A.M. 2000. The flavonoids of four Pistacia species in Egypt. Biochemical systematics and ecology, 28(9): 915-917.
33. Keikhaei, F. Naghsh, N. and Modaresi, M. 2014. The comparison between hydroethanolic extraction of pistacia Atlantica and Suzin effects on growth inhibition of K562 cell line in vitro condition. Arak medical university journal, 17(87): 66-73.
34. Kornsteiner, M. Wagner, K.H. and Elmadfa, I. 2006. Tocopherols and total phenolics in 10 different nut types. Food chemistry, 98(2): 381-387.
35. Küçüköner, E. and Yurt, B. 2003. Some chemical characteristics of Pistacia vera varieties produced in Turkey. European food research and technology, 217: 308-310.
36. Martorana, M. Arcoraci, T. Rizza, L. Cristani, M. Bonina, F.P. Saija, A. Trombetta, D. and Tomaino, A. 2013. In vitro antioxidant and in vivo photo protective effect of pistachio (Pistacia vera L., variety Bronte) seed and skin extracts. Fitoterapia, 85: 41-48.
37. Magiatis, P. Melliou, E. Skaltsounis, A.L. Chinou, I.B. and Mitaku, S. 1999. Chemical composition and antimicrobial activity of the essential oils of Pistacia lentiscus var. chia. Planta medica, 65(08): 749-752.
38. Mirdehghan, H. 2021. Study on storage of fresh pistachio cultivar ahmad aghaie using gamma aminobutyric acid and carnuba wax. Journal of food science and technology (Iran), 18(110): 153-163. DOI: 10.29252/fsct.18.01.14. (In Persian)
39. Miniati, E. 1981. Anthocyanin pigment in the pistachio nut. Fitoterapia, 52: 267-271.
40. Mokhtarpour, A. Naserian, A.A. Valizadeh, R. Mesgaran, M.D. and Pourmollae, F. 2014. Extraction of phenolic compounds and tannins from pistachio by-products. Annual research & review in biology, 4(8): p. 1330.
41. Montazeri, N. Ojani, S.H. 2018. Application of catalysts in the synthesis of heterocyclic compounds. Islamic Azad University (Tonekabon) Publications, First Edition. (In Persian)
42. Molyneux, P. 2004. The use of the stable free radical diphenylpicrylhydrazyl (DPPH0) for estimating antioxidant activity Songklanakarin journal of science and technology, 26(2): 211-219.
43. Nadernejad, N. Ahmadimoghadam, A. Hossyinifard, J. and Poorseyedi, S. 2013. Study of the rootstock and cultivar effect in PAL activity, production of phenolic and flavonoid compounds on flower, leaf and fruit in Pistachio (Pistacia vera L.). Journal of plant biological sciences, 5(15): 95-110.
44. Negi, P.S. Jayaprakasha, G.K. and Jena, B.S. 2003. Antioxidant and anti-mutagenic activities of pomegranate peel extracts. Food chemistry, 80(3): 393-397.
45. Nishimuta, S. Taki, M. Takaishi, S. Iijima, Y. and Akiyama, T. 2000. Structures of 4-aryl-coumarin (neo flavone) dimers isolated from Pistacia chinensis BUNGE and their estrogen-like activity. Chemical and pharmaceutical bulletin, 48(4): 505-508.
46. Ojani, S. Montazeri, N. Mohammadi Zeydi, M. Ghane, M. 2023. Phytochemical examination of the hydroalcoholic extract of Polylophium involucratum (Pall.) Boiss. harvested from the heights of the Javaherdeh - Ramsar and determination of its cytotoxic effects on chronic myeloid leukemia. Iranian journal of biological sciences, 18: 49-62. https://doi.org/ 10.30495/zisti.2023. 1993274.1169. (In Persian).
47. Ojani, S. and Amirkhani, S. 2022. Antibacterial activity of methanolic extract of Pistacia atlantica fruits using disk diffusion method for the treatment of urinary tract infections. 23rd International congress of microbiology of Iran. Faculty of medicine, Tehran University of medical sciences.
48. Ojani, Sh. 2015. Quantitative and qualitative study of the essential oil and alcoholic extract of the Polylophium involucratum (Pall.) Boiss. harvested in the highlands of Ramsar using microwave irradiation and its use to synthesis of silver nanoparticles. (M.Sc) Thesis: Islamic Azad University, Tonekabon Branch. (In Persian)
49. Oliveira, I. Sousa, A. Ferreira, I.C. Bento, A. Estevinho, L. and Pereira, J.A. 2008. Total phenols, antioxidant potential and antimicrobial activity of walnut (Juglans regia L.) green husks. Food and chemical toxicology, 46(7): 2326-2331.
50. Ozel, M.Z. Gogus, F. Hamilton, J.F. and Lewis, A.C. 2004. The essential oil of Pistacia vera L. at various temperatures of direct thermal desorption using comprehensive gas chromatography coupled with time-of-flight mass spectrometry. Chromatographia, 60: 79-83.
51. Panahi, B. 2001. Pistachio Guide planting and harvest. Publication agriculture. P: 20-42.
52. Pearson, T.C. Slaughter, D.C. and Studer, H.E. 1994. Physical properties of pistachio nuts. Transactions of the ASAE, 37(3): 913-918.
53. Pourshamsian, K. and Ojani, S. 2016. Phytochemical screening of the aqueous extract of seeds of Polylophium involucratum (Pall.) Boiss. from Ramsar-Iran. Planta medica, 82(05): p. PC62. DOI:10.1055/s-0036-1578764. (In Persian)
54. Pumilia, G. Cichon, M.J. Cooperstone, J.L. Giuffrida, D. Dugo, G. and Schwartz, S.J. 2014. Changes in chlorophylls, chlorophyll degradation products and lutein in pistachio kernels (Pistacia vera L.) during roasting. Food research international, 65: 193-198.
55. Rajaei, A. Barzegar, M. Mobarez, A.M. Sahari, M.A. and Esfahani, Z.H. 2010. Antioxidant, anti-microbial and anti-mutagenicity activities of pistachio (Pistachia vera) green hull extract. Food and chemical toxicology, 48(1): 107-112.
56. Rezaei, P.F. Fouladdel, S. Ghaffari, S.M. Amin, G. and Azizi, E. 2012. Induction of G1 cell cycle arrest and cyclin D1 down-regulation in response to pericarp extract of Baneh in human breast cancer T47D cells. Daru Journal of pharmaceutical sciences, 20: 1-5.
57. Rezaei, P.F. Fouladdel, S. Hassani, S. Yousefbeyk, F. Ghaffari, S.M. Amin, G. and Azizi, E. 2012. Induction of apoptosis and cell cycle arrest by pericarp polyphenol-rich extract of Baneh in human colon carcinoma HT29 cells. Food and chemical toxicology, 50(3-4):1054-1059.
58. Rohrdanz E, Ohler S, Tran-Thi Q, Kahl R. 2002. The phytoestrogen daidzein affects the antioxidant enzyme system of rat hepatoma H411E cells. Journal of nutrition. 132: 370-5.
59. Singleton, V.L. Orthofer, R. and Lamuela-Raventós, R.M. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. In methods in enzymology Academic press, 299: 152-178.
60. Sharma, O.P. and Bhat, T.K. 2009. DPPH0 antioxidant assay revisited. Food chemistry, 113(4): 1202-1205
61. Stockert, J.C. Horobin, R.W. Colombo, L.L. and Blázquez-Castro, A. 2018. Tetrazolium salts and formazan products in cell biology: viability assessment, fluorescence imaging, and labeling perspectives. Acta histochemica, 120(3): 159-167.
62. Tomaino, A. Martorana, M. Arcoraci, T. Monteleone, D. Giovinazzo, C. and Saija, A. 2010. Antioxidant activity and phenolic profile of pistachio (Pistacia vera L., variety Bronte) seeds and skins. Biochimie, 92(9): 1115-1122.
63. Villar, A. Sanz, M.J. and Paya, M. 1987. Hypotensive effect of Pistacia lentiscus L. International journal of crude drug research, 25(1): 1-3.