One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation

Subject Areas : Polymer

Mohsen Sargordan Arani ¹ , Behrooz Mirza ² , Mohammad Moghanlou ³

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Received: 2017-01-16 Accepted : 2017-01-16 Published : 2017-01-01

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Abstract :

Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thiourea .H3 BO3 , H2 C2 O4 , Me3 SiCl (TMSCl) using as catalyst and compared product yield.Products were characterized with IR, 1 H NMR, 13C NMR and mass spectroscopy