A simple, solvent-free four-component domino synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by copper (II) oxide

Subject Areas : Polymer

Farzaneh Mohamadpour ¹ (Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran)

Received: 2019-09-09 Accepted : 2019-09-09 Published : 2019-10-01

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Abstract :

An eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of copper (II) oxide (CuO) under solvent-free conditions in high yields. The advantages of this one-pot procedure is environmentally friendly, efficient and economic availability of the catalyst, short reaction times, solvent-free conditions and clean reaction profiles.