Trichloroacetic Acid as an Efficient Catalyst for One-pot Synthesis of Highly Functionalized Piperidines via multi-component Reaction

Hazeri, Nourallah; Fereidooni, Elham

Manuscript ID : 518048 Visit : 183 Page: 81 - 89

20.1001.1.20083815.2015.9.4.8.1

Article Type: Original Research

Trichloroacetic Acid as an Efficient Catalyst for One-pot Synthesis of Highly Functionalized Piperidines via multi-component Reaction

Subject Areas : Polymer

Nourallah Hazeri ¹ , Elham Fereidooni ²

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Received: 2015-12-28 Accepted : 2015-12-28 Published : 2015-10-01

Keywords:

Abstract :

Trichloroacetic Acid (TCA) was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes andβ-keto esters in MeOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and an easy work-up.

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Trichloroacetic Acid as an Efficient Catalyst for One-pot Synthesis of Highly Functionalized Piperidines via multi-component Reaction