Dispersive Micro-Solid-Phase Extraction using Graphene Oxide/Polydopamine-Polyacrylamide Nanocomposite Coupled with HPLC-UV for Determination of Phenobarbital in Plasma Samples

Subject Areas : Polymer

Sima Khiltash ¹ , Rouhollah Heydari ² , Majid Ramezani ³ , Tahereh Momeni Isfahani ⁴

1 - Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran.
2 - Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3 - Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran.
4 - Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran.

Received: 2021-11-21 Accepted : 2021-11-21 Published : 2022-01-01

Keywords:

Abstract :

Graphene oxide/polydopamine-polyacrylamide nanocomposite was synthesized by a simple method and used as adsorbent for dispersive micro-solid-phase extraction of phenobarbital in plasma samples. The adsorbent was characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy–energy dispersive spectroscopy and thermal gravimetric analysis. The results show that functionalization of graphene oxide by polymeric materials can enhance the sorption properties and thermal stability of the prepared adsorbent. Influential parameters on the extraction efficiency of Phenobarbital including adsorbent amount, elution solvent and its volume, sorption and desorption times and pH of sample solution were investigated and optimized. Under the optimized conditions, limits of detection and quantitation values were 1.4 and 5ng/mL, respectively. Relative recovery data for several real samples were obtained within the range of 84.0-98.0% with a relative standard deviation less than 7.2%. The proposed method was successfully applied to quantitative determination of phenobarbital in plasma samples.

References:

[1]. M.G. Papich, Papich Handbook of Veterinary Drugs, Fifth Edition, Elsevier, St. Louis, Missouri
63043, Pages 720-723 (2021)
[2]. I. Salimikia, R. Heydari, F. Yazdankhah, J. Iran.Chem. Soc., 15, 1593 (2018).
[3]. M. Rashidipour, R. Heydari, A. Feizbakhsh, P. Hashemi, Nat. Prod. Res., 29, 621 (2015).
[4]. M. Rashidipour, R. Heydari, A. Feizbakhsh, P. Hashemi, J. AOAC Int., 97, 1109 (2014).
[5]. M. Rahimi, S. Bahar, R. Heydari, S.M. Amininasab, Microchem. J., 148, 433 (2019).
[6]. A. Mehdinia, A. Ghassempour, H. Rafati, R. Heydari, Anal.Chim.Acta, 587, 82 (2007).
[7]. M. Rashidipour, R. Heydari, Anal.Bioanal.Chem. Res., 5, 307 (2018).
[8]. R. Heydari, M.R. Darabi Bazvand, Food Anal. Methods, 12, 1949 (2019).
[9]. Y. Liu, Y. Liu, Z. Liu, X. Zhao, J. Wei, H. Liu, X. Si, Z. Xu, Z. Cai, J. Hazard. Mater.,392,
122251 (2020).
[10]. Z. Mehrani, H.Ebrahimzadeh, E. Moradi, Microchim. Acta, 187, 401 (2020).
[11]. M. Mohammadnia, R. Heydari, M.R. Sohrabi,J. Environ. Sci. Health B, 55, 293 (2020).
[12]. M. Ghani, S.M. Ghoreishi, M. Shahin, M. Azamati, Microchem. J., 146, 798 (2019).
[13]. R. Venson, A.S. Korb, G. Cooper, J.Chromatogr.B, 1108, 32 (2019).
[14]. R. Shariati, B. Rezaei, H.R. Jamei, A.A. Ensafi, Talanta, 194, 143 (2019).
[15]. P. Mohammadi, M. Masrournia, Z. Eshaghi, M. Pordel, Microchem. J., 159 105542 (2020).
[16]. S. Yaripour, S. Ebrahimi, A. Mohammadi,Braz. J. Pharm. Sci., 56, e17839(2020).
[17]. S. Zadaliasghar, E. Rahimpour, M. Khoubnasabjafari, M.H. Pournaghi-Azar, A. Nokhodchif,
A. Jouyban, J. Mol. Liq., 316, 113891 (2020).
[18]. R. Zhu, Y. Dong, X. Cai, C. Huang, Molecules, 24, 1494(2019).
[19]. X. Geng, J. Wang, J. Ye, S. Yang, Q. Han, H. Lin, F. Liu,Sep. Purif. Technol., 244, 116857
(2020).
[20]. R. Liu, S. Liang, X. Tang, D. Yan, X. Li, Z. Yu,J. Mater. Chem., 22, 14160 (2012).
[21]. X. Huang, K. Qiao, L. Li, G. Liu, X. Xu, R. Lu, H. Gao, D. Xu, Sci. Rep., 9, 8919 (2019). 

[22]. F. Tan, M. Liu, S. Ren,Sci. Rep.,7, 5735 (2017).
[23]. X. Wang, Y. Zhao, E. Tian, J. Li, Y. Ren, Adv. Mater. Interfaces, 5, 1701427 (2018)
[24]. M. Cheng, L. Huang, Y. Wang, Y. Zhao, J. Tang, Y. Wang, Y. Zhang, M.Hedayati, M.J.
Kipper, S.R.Wickramasinghe, J. Mater.Sci., 54, 252 (2019).
[25]. M.R. Manafi, P. Manafi, S. Agarwal, A.K. Bharti, M. Asif, V.K. Gupta, J. Colloid Interface
Sci., 490, 505 (2017).
[26]. B. Chen, Y. Cao, H. Zhao, F. Long, X. Feng, J. Li, X. Pan,J. Hazard. Mater., 392, 122263
(2020).
[27]. S. Seraj, M.N. Lotfollahi, A. Nematollahzadeh,React. Funct. Polym., 147, 104462 (2020).
[28]. J. Dai, M. Liang, P. Ren, Y. Fu, F. Wang, X. Ge, T. Zhang,Mater. Lett., 266, 127487 (2020).
[29]. Z. Xiao, Y. Li, C. Liang, R. Bao, M. Yang, W. Yang, Appl. Surf. Sci., 499, 143934 (2020).
[30]. L. Han, X. Lu, M. Wang, D. Gan, W. Deng, K. Wang, L. Fang, K. Liu, C.W. Chan, Y. Tang,
L.T. Weng, H. Yuan, Small, 13, 1601916 (2017).
[31]. Y.L. Dong, H,G. Zhang, Z. Ur Rahman, L. Su, X.J. Chen, J. Hu, X.G. Chen, Nanoscale, 4,
3969 (2012).
[32]. T. Touqeer, M.W. Mumtaz, H. Mukhtar, A. Irfan, S. Akram, A. Shabbir, U. Rashid, I.A.
Nehdi, T.S.Y. Choong, Energies, 13, 177 (2020).
[33]. A.M. Dumitrescu, G. Lisa, A.R. Iordan, F. Tudorache, I. Petrila, A.I. Borhan, M.N. Palamaru,
C. Mihailescu, L. Leontie, C. Munteanu,Mater. Chem. Phys., 156, 170 (2015).
[34]. M. Bialer, Epilepsia, 53, 3 (2012).