Mefenamic acid as Environmentally Catalyst for Threecomponent Synthesis of Dihydropyrano [2,3-c]Chromene and Pyrano[2,3-d]Pyrimidine Derivatives

Subject Areas : Polymer

Soheila Asadpour Behzadi ¹ , Enayatollah Sheikhhosseini ^{2 *} , Sayed Ali Ahmadi ³ , Dadkhoda Ghazanfari ⁴ , Mohammadreza Akhgar ⁵

1 - Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.
2 - Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.
3 - Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.
4 - Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.
5 - Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

Received: 2020-05-27 Accepted : 2020-05-27 Published : 2020-07-01

Keywords:

Abstract :

Pills of Mefenamic acid were employed as effective catalysts in the three component reaction of aromatic aldehydes, malononitrile, as well as 4-hydroxycoumarin or barbituric acid in aqueous solution, using reflux conditions in order to synthesize derivatives of dihydropyrano[2,3-c]chromene and pyrano[2,3-d]pyrimidine, correspondingly. Among the benefits of this technique, higher efficiency, shorter reaction time, along with better reaction indices could be mentioned.