Solvent-free Biginelli Reaction Catalyzed to Synthesis of Biologically Active 3,4-dihydropyrimidin-2-(1H) –ones/thiones Derivatives
Subject Areas : Polymer
1 - Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Keywords:
Abstract :
A convenient and highly efficient procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives via one-pot three-component Biginelli condensation of arylaldehydes,urea/thiourea and ethyl/methyl acetoacetate in the presence of Zn(SO4)2.7H2Oas anefficient, readily and inexpensive catalyst under solvent-free conditions have been studied. Thisprotocol has advantages such as readily available and non-toxic catalyst, short reaction times, goodto high yields, solvent-free conditions, facile reaction profiles, high atom-economy and simplework-up.