4-Sulfobenzoic Acid as an Efficient Catalyst for the Preparation of 3,4-dihydropyrimidin-2-(1H)-ones Under Solvent-free Conditions

Subject Areas : Polymer

Ali Oudi ¹ , Nourallah Hazeri ² , Maryam Fatahpour ³

1 - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
2 - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
3 - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

Received: 2018-12-22 Accepted : 2018-12-22 Published : 2019-01-01

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Abstract :

In this research, one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones havebeen developed using Biginelli reaction from the interaction between ethyl/methyl acetoacetate,aromatic aldehydes, and urea/thiourea in the presence of 4-sulfobenzoic acid as a new, effective,inexpensive, and available bronsted acid. Avoidance of toxic and dangerous solvents, easy isolationof products without the need of column chromatography, high yields, and short reaction time aresome important features of the present method.