Synthesis and Screening of Some New Isatin Containing Thiazole Derivatives for Antimicrobial Activity

Subject Areas : Polymer

Suman Adhikari ^{1 *} , S. B. Bari ² , A. Samanta ³

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Received: 2015-11-16 Accepted : 2015-11-16 Published : 2014-01-01

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Abstract :

In the present work, a series of new N’-[{5-(4-aryl) 1,3-thiazol-2yl}carbohydrazide-methyl]- 3(4-arylimino) indol-2-one analogs (5a-g) had heen synthesized from 3-(4-arylimino)-2-oxo- 1-indole-acetylthiosemicarbazide (4a-g) in ethanol, in the presence of phenacyl bromide or substituted phenacyl bromides. The compound 5e was characterized by its elemental analysis, IR, 1 HNMR and Mass Spectroscopy. The synthesized compounds (5a-g) were evaluated for in vitro antibacterial activity and antifungal activity against various strains of bacteria and fungi.