Preparation of Antimicrobial Hydrogel Film Based on Chitosan, Poly Vinyl Poly Pyrrolidone, and Copper Ions

Subject Areas : Polymer

Ensieh Ghasemian Lemraski ¹ (Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran)
Elaheh khajehali ² (Department of Food Hygiene, Faculty of Veterinary Medicine, Ilam University, Ilam, Iran)
Maryam Dashti ³ (Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran)
Shirin Alibeigi ⁴ (Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran)

Received: 2023-07-31 Accepted : 2023-07-31 Published : 2023-07-01

Keywords:

Abstract :

Easy operation, eco-friendliness, and high capacity are the advantages of using hydrogelbased membranes in water treatment, medicine, drug delivery, wound care products, and protective clothing. In the present work, we tried to prepare bio-films with antimicrobial ability by incorporating of Cu ions in chitosan and poly vinyl poly Pyrrolidone. The prepared film was characterized by the thermal gravimetric analysis (TGA), Fourier transforms infrared spectroscopy (FT IR), scanning electron microscopy with X-ray microanalysis (SEM-EDS), and X-ray powder diffraction. The antimicrobial ability of the prepared film was confirmed due to the analysis of antibacterial assay results by using gram-positive and gram-negative bacteria. Based on the achieved data, the prepared multifunctional bio-film could be a considerable candidate in packing industry, especially in medical compounds, tissue engineering, and pharmacology.

References:

1. R.J. Turner,Microb. Biotechnol., 10,1062 (2017).
   2. A. Nivetha, C. Sakthivel, G. Rajagopal, S. Nandhabala, J. Hemalatha, C. Senthamil, I.Prabha, Surf. Interfaces, 35, 102388 (2022)
   3. M. Azizi-Lalabadi,A. Ehsani, B.Divband andM. Alizadeh Sani,Sci. Rep, 9,17439 (2019).
   4. S. Tang,J. Zheng,Adv. Healthcare. Mater.,7,1701503 (2018).
   5. B. Ma, G. Hu, S. Guo, Q. Zeng, Y. Chen, D. Hwan Oh, Y. Jin, X. Fu,Food Res. Int., 161,111638 (2022).
   6. S. Ghorbanizadeh, F. Karami, S. Delfani, M. Shakibaie, A. Razlansari, F. Rezaei,Ann.Med. Surg., 81, 104291(2022).
   7. F. Naserian, A. S. Mesgar, Colloids Surf. B: Biointerfaces, 218, 112729 (2022).
   8. J. Li, S. Zivanovic, P.M. Davidson, K. Kit,Carbohydr. Polym., 79, 786(2010).
   9. G. Borkow, J. Gabbay,The FASEB J., 18,1728 (2004).
   10. B. Das, S. Patra. Nanostruct. Antimicrob. Ther.,1 (2017).
   11. T. Liu, K. Cui, C-X. Li, Y. Chen, Q. Wang, X. Yuan, Y. Chen, J. Liu, Q. Zhang,Chemosphere, 311, 2023(2022).
   13. M.F. Parveen, A. Amala Jeya Ranchani, V. Parthasarathy, R. Anbarasan, SurfaceInterfaces, 25,101197(2021).
   14. I. Ranatunge, S. Adikary, P. Dasanayake, C.D. Fernando, P. Soysa, Int J anal Chem. 1(2017).
   15. W. Zhang, P. Wang, Y. Deng, X. He, X. Yang, R. Chen, Z. Lei, J. Environ. Chem.Engin., 9, 106760(2021).
   16. D.H. Ngo,T. Vo,D.N. Ngo,K.H. Kang, G.Y. Je,H. Pham, H. Byun, S.K. Kim, Food Hydrocoll., 51,200 (2015).
   17. K. Kalanidhi, P. Nagaraaj, Chem. Phys. Let.t, 805, 139960(2022).
   18. J. Zhang, K. Chen, C. Ding, S. Sun, Y. Zheng, Q. Ding, B. Hong, W. Liu, Int. J. Biol.Macromol., 206, 591(2022).
   19. F. Haghighat and M. Mokhtary,. Polym. Plast. Technol. Eng.,56, 794 (2017).
   20. M.S.Usman, M.E. El Zowalaty, K. Shameli, N. Zainuddin, M. Salama, N.A. Ibrahim,Int. J. Nanomedicine, 8, 4467(2013).
   21. L. Zheng, M. Tang, Y. Wang, D. Hou, X. Li, J. Wang, Sep. Puri. Technol.,299,121807(2022).
   22. R. Poonguzhali, S.K. Basha, Kumari VS, Polym. Bull.,74,2185 (2017). 23. A. Abedini, E. Saion,F. Larki, A. Zakaria, M. Noroozi, N. Room, Int. J. Mol. Sci.,13,11941 (2012).
   24. G. Arandhara, P. K. Saikia, Physica B: Condensed Matter., 610, 0921(2021).
   25. J.F.W. Bowles,S. Suárez,H.M. Prichard, P.C. Fisher, Mineral Mag., 82,S223 (2018).
   26. S. Madhu, Yuvarajan Devarajan, M. Balasubramanian, M. Prithivi Raj, Mater. Lett.,329, 133195(2022).
   27.M. Fernandes Queiroz, K.R. Melo, D.A. Sabry, G.L. Sassaki andH.A. Rocha, Mar.Drugs,13,141 (2014).
   28. R. Sergi, D. Bellucci, R. V. Salvatori Cannillo, Material Basel,13,2819 (2020).
   29. E. Marsano,S. Vicini, J. Skopiǹska, M. Wisniewski, Macromol. Symp., 218,251 (2004).
   30. I. Corazzari, R. Nisticò, F. Turci,M.G. Faga, F. Franzoso, S. Tabasso,G. Magnacca,Polym. Degrad. Stabil.,112,1 (2015).
   31. S.K. Mishra,D.S. Mary, S. Kannan, Int. J. Biol. Macromol., 95,928 (2017).
   32. A.K. Hatterjee, R. Chakraborty, T. Basu, Nanotechnol., 25,135101 (2014).
   33. H. Qamar, S. Rehman, D.K. Chauhan, A.K. Tiwari, V. Upmanyu, Int. J. Nanomedicine,152541 (2020).
   34. J.P. Ruparelia, A.K. Chatterjee, S.P. Duttagupta, S. Mukherj, Acta Biomater.,4,707(2008).
   35. R. De Souza,P. Zahedi, C.J. Allen and M. Piquette-Miller, Biomaterial.,30, 3818 (2009).
   36. N. De Vietro, A. Conte, A. L. Incoronato, M. A. Del Nobile, F. Fracassi, Innov. Food Sci. Emerg. Thechnol.,41,130(2017).
   37. M. Cieślak, D. Kowalczyk, M. Krzyżowska, M. Janicka, E. Witczak, I. Kamińska,Materials (Basel),15, 6164(2022).
   38. Ren G, Huang L, Hu K, J. Mater. Sci.Technol., 117, 158 (2022).
   39. S. Zhang, Y. Yu, H. Wang, L. Ren, K.Yang, J. Mech. Behav. Biomed. Mater., 125,104926(2022).