Three-component Process for the Synthesis of Some Thiophene Derivatives Using Water as a Green Media
Subject Areas : Polymer
1 - Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan, Iran.
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Abstract :
A convenient and efficient three-component reaction to a one-pot synthesis of thiophene derivatives from activated acetylenic compounds and ethyl 2chloroacetoacetate in the presence of tetramethyl thiourea in water lead to the formation of thiophenes in good yields.