Application of Solid Dispersion Method for Increasing Solubility of Remeron as an Antidepression Drug

Subject Areas : Medicinal Chemistry

Nadia Afshari ¹ , Zahra Jafariazar ² , Seyed Ali Sobhanian ³

1 - دانشکده علوم داروئی-دانشگاه علوم پزشکی آزاد اسلامی تهران-تهران-ایران
2 - دانشکده علوم داروئی-دانشگاه علوم پزشکی آزاد اسلامی تهران-تهران-ایران
3 - دانشیار، گروه مدیریت و اقتصاد دارو، دانشکده داروسازی، دانشگاه علوم پزشکی آزاد اسلامی تهران، ایران

Received: 2024-05-14 Accepted : 2024-08-12 Published : 2024-12-22

Keywords: Depressive disorders, Drugs’ solubility, Remeron (Mirtazapine), Solid Dispersion Method, Carriers,

Abstract :

Since the solubility behavior of drugs is one of the challenging aspects in the development of their formulations, various techniques have been proposed to improve their dissolution rates, including using solvents, solid dispersions and surfactants. Remeron (Mirtazapine, I) is a drug that widely used in the treatment of depressive disorders. This drug has a weak dissolution rate in water, which causes decreasing in absorption, therapeutic benefit and its excretion without effectiveness. Therefore, the aim of this study is increasing the solubility of this drug using solid dispersion method, in which the hydrophobic drug is dispersed inside a hydrophilic matrix. In this research, solid dispersions of I using different carriers including mannitol and polyethylene glycols (PEGs) in different ratios with solvent evaporation and physical mixing methods were prepared. Then, the solubility of the prepared formulations was investigated by determining the saturation solubility. The results showed that the saturation solubility of all formulations increased compared to pure Mirtazapine and the superior formulation was selected. It can be concluded that solid dispersion method with PEGs (as carriers) has been a suitable technique to improve the dissolution rate of I.