Synthesis of 2-butenedioates viamulticomponent reaction of isoquinoline

Subject Areas :

Received: 2025-03-28 Accepted : 2025-03-28 Published : 2025-03-28

Keywords: Synthesis of 2-butenedioates viamulticomponent reaction of isoquinoline,

Abstract :

Isoquinoline reacts smoothly with dimethyl acetylenedicarboxylate (DMAD) in the presence of amides to produce dimethyl (E)-2-[1-[aryl(alkyl)carbonylamino]-2(1H)-isoquinolinyl]-2-butenedioates. Also, quinoline reacts with DMAD in the presence of benzamide to produce dimethyl (E)-2-[1-[(phenylcarbonyl)amino]-2(1H)- quinolinyl]-2-butenedioate.