Synthesis of benzofuran derivatives using one-pot multicomponent reaction of isocyanides via ZnO-NRs
Subject Areas :
Keywords: Strecker reaction, Antioxidant ability, –amino nitrile benzofurans, Five component reaction, DPPH radical scavenging, ZnO nanorod,
Abstract :
In this work ZnO-NR as reusable catalyst promoted Strecker-type reaction of 2,4-dihydroxyacetophenone, isopropenylacetylene, trimethylsilyl cyanide, primary amines and isocyanides carried out at ambient temperature under solvent-free conditions and produced amino nitriles benzofuran derivatives in high yields. Short time of reaction, high yields of product, easy separation of catalyst and products are some benefits of this procedure.