Green synthesis of oxazole derivatives using three component reactions of α-hydroxy carbonyls

Subject Areas : Iranian Journal of Organic Chemistry

Received: 2023-12-02 Accepted : 2023-12-30 Published : 2024-01-23

Keywords: Acid chlorides, Ammonium thiocyanate, Et3N, 3-Hydroxy-2-butanone, Oxazole.,

Abstract :

An efficient synthesis of oxazole derivatives is described via an one-pot reaction between isothiocyanates, ammonium acetate, benzoin or 3-hydroxy-2-butanone and triethylamine.

References:

Mechanistic Investigation of the [1+4] Cycloaddition Reaction Between Alkyl Isocyanides and 3-benzylidene-2,4-pentanedione: A Theoretical Study
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Synthesis and characterization of PTS and PDATS: Two maiden functionalized energetic polymers having tetrazole and triazine rings
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BF3 catalyzed hydroarylation reactions of arylsubstituted alkynes with different electron rich arenes
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Synthesis of some 3-indolyl heterocycles and evaluation of its antimicrobial activity
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1,3,4-Thiadiazole rings as π-spacers in triphenylamine based dyes: A density functional theory study of reactivity, UV/Visible spectra, structural and optical properties
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Graphical Abstract
Print Date : 2014-05-01

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Green synthesis of oxazole derivatives using three component reactions of α-hydroxy carbonyls