An efficient synthesis of new derivatives of thiazole using multicomponent reactions

Subject Areas : Iranian Journal of Organic Chemistry

Mahboubeh Ghasemian Dazmiri ¹ , Loghman Moradi ²

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Received: 2023-09-17 Accepted : 2023-09-17 Published : 2023-08-01

Keywords: Three-component reaction, Primary Amines, thiazole, green chemistry, 1-methyl imidazole,

Abstract :

N-methyl imidazole accelerated synthesis of thiazole derivatives by employing of three-component reactions of primary amines, dialkyl acetylenedicarboxylates and isothiocyanates under solvent-free conditions at room temperature in a good yield. The above synthetic procedure offers rapid access to novel and diversely substituted thiazole derivatives.