An efficient synthesis of new derivatives of thiazole using multicomponent reactions
Subject Areas : Iranian Journal of Organic Chemistry
Mahboubeh Ghasemian Dazmiri
1
(
)
Loghman Moradi
2
(
)
Keywords: Three-component reaction, Primary Amines, thiazole, green chemistry, 1-methyl imidazole,
Abstract :
N-methyl imidazole accelerated synthesis of thiazole derivatives by employing of three-component reactions of primary amines, dialkyl acetylenedicarboxylates and isothiocyanates under solvent-free conditions at room temperature in a good yield. The above synthetic procedure offers rapid access to novel and diversely substituted thiazole derivatives.