Evaluation of adsorption potential of Buprenorphine drug from blood plasma by its molecular imprinted polymer; a joint experimental and theoretical study

Subject Areas : Iranian Journal of Organic Chemistry

Maryam Khanlari ¹ , Bahram Daraei ² , Leila Torkian ³ , Maryam Shekarchi ⁴ , Mohammad Reza Manafi ⁵

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Received: 2023-02-26 Accepted : 2023-02-26 Published : 2022-11-01

Keywords: Solid phase extraction, Drug delivery, density functional theory, Molecular Imprinted Polymer, Buprenorphine,

Abstract :

In this paper, we have described the use a molecular imprinted polymer (MIP) templated with Buprenorphine (BUP)drug for adsorption of its residue from the biological samples. Preparing this MIP by BUP (as the molecular template) causes to formation of billions of special active sites, which only accept this drug as the guest. Thus, this MIP could absorb BUP from the system in different conditions. The successful use of such MIPs in adsorption BUP from the blood which is described in this work, shows the possibility of using this sorbent, in solid phase extraction, in adsorption/removal, and in drug delivery application of this important drug in the human blood plasma. To do this, after preparing the mentioned MIP, the adsorption process of the drug was investigated by HPLC system. In addition, the results have showed that the obtained MIP is a suitable candidate for the solid phase adsorption of the drug from the blood plasma. Also, the collected data showed that using the MIP is more suitable compared to NIP in the examined processes. Moreover, both of the MIP-, and non-imprinted polymers (NIP)-drug systems were designed and optimized by light of the density functional theory (DFT) approach. The reached results showed that the theoretical calculations would support the experimental data, confirming the priority of adsorption of the drug by MIP compared to NIP.