Wood-ash (WA): a highly efficient biocatalyst for the synthesis of α-amino nitrile derivatives using one-pot multicomponent reaction

Subject Areas : Iranian Journal of Organic Chemistry

Rezvaneh Rostamian ¹ , Daryoush Zareyee ² , Mohammad Khalilzadeh ³

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Received: 2022-12-21 Accepted : 2022-12-21 Published : 2022-08-01

Keywords: Multicomponent reaction, α-amino nitrile benzofuran, Wood ash,

Abstract :

Research on heterogeneous catalysts with characteristics such as recyclability, insolubility, and easy separation hasbeen recently advanced by green chemistry. Wood ash, with high amounts of the abovementioned metal oxides, seems asuitable alternative used in reactions that need base catalysts. To synthesize α-aminonitrile benzofuran, the 2,4-hydroxyacetophenone and isopropenyl acetylene was mixed and stirred in the presence of Water Extract of Wood Ash(WEWA) catalyst, followed by the addition of amine derivatives and stirring over a 15-minute period. The addition oftrimethylsilyl cyanide and its stirring for another 120 minutes were the next steps. Various natural resources were used toprepare several wood ash catalysts using different combustion temperatures. FT-IR, SEM, TEM, and XRD methods wereutilized to characterize the catalysts. The catalytic efficacy of the resulting catalysts was examined in synthesizing derivatives of α-amino nitrile. As shown by the experimental results, the preparation of the catalysts at a temperature of 850 °C effectively promoted the multicomponent synthesis of α-amino nitrile derivatives in aqueous media, leading to significantly great productivity.