Cell suspension culture of yew: an alternative method of taxol production
Subject Areas : Phytochemistry
raheleh gorzi
1
(the Department of Horticulture, Faculty of Agriculture University of Zanjan, IRAN)
Keywords: Cell suspension culture, Taxol, Secondary metabolite, Anti-cancer drug, taxus,
Abstract :
Taxol is one of the most important anti-cancer drugs in the world, which is obtained from the genus of the Taxus. Taxol, with its antimicrobial properties, causes the death of proliferating cells by preventing the formation of abnormally dividing spindles. Abnormal division stops DNA transcription in the G2 / M division of mitosis and thus causes the proliferation of proliferating cells. Due to the low amount of taxol in the tissues of yew and also the very low growth of this plant, meeting the therapeutic need for this drug is the most important issue facing scientists. Commercially, taxol synthesis seems unlikely due to limited resources and the possibility of over-consumption of a natural product that could be found in endangered yew species. Therefore, a suitable alternative method for taxol production should be used. Yew cell suspension culture is one of the most important alternatives for long-term and sustainable production of taxol. This review is about cell suspension culture in different yew species.
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