One pot synthesis of conjugated chalcone-quinoxalines using an organocatalyst under ultrasonic mediation

Subject Areas :

Kiana Darvishi ¹ (Department of chemistry, Takestan Branch, Islamic Azad University, Takestan, Iran)

Received: 2022-03-14 Accepted : 2022-03-14 Published : 2021-12-01

Keywords: Chalcone, Quinoxaline, Ultrasonic mediation, Organocatalysts, Chalcon-quinoxaline,

Abstract :

Ultrasonic irradiation was effectively used for the synthesis of one pot chalcon-quinoxaline derivatives with high efficiency and short time. The products are obtained by mixing parahydroxy acetophenone and various aldehydes or parahydroxy benzaldehyde with different ketones and then adding 2,6-dichloroquinoxaline, in the presence of catalytic amounts of pyrrolidine as a organocatalyst and DMF as a solvent. These conjugated chalcon-quinoxaline derivatives have been shown to have good anticancer activity.

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Synthesis and spectroscopic study of a new diamidophosphoester, (4-CH3-C6H4O)((CH3)2CHNH)2P(O)
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One pot synthesis of conjugated chalcone-quinoxalines using an organocatalyst under ultrasonic mediation