Condensation of thiohydrazide analogues with 4-bromo-3, 6-dichloropyridazine: an efficient rout to pyridazino[4, 3-e][1, 3, 4]thiadiazines.

Subject Areas :

Mohsen Nikpour ¹ (Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz 6134968875, Iran)
Mahsa Salehpoor Kiani ² (Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz 6134968875, Iran)

Received: 2016-06-01 Accepted : 2016-06-01 Published : 2012-05-01

Keywords: 4-bromo-3, 6-dichloropyridazine, nucleophilic displacement, Mass Spectroscopy,

Abstract :

Some new 3-(alkylsulfanyl)- 7-chloro-1-phenyl-1H-pyridazino [4,3-e][1,3,4]thiadiazine were synthesized by treatment of the alkyl-2-phenylhydrazinecarbodithioates with 4-bromo-3,6-dichloropyridazine in alkaline acetonitril. Orientation of the reaction has been determined by X-Ray crystallography technique. The chlorine atom on the number 7 position of these products was replaced by secondary amines in reflux condition.

References:

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Condensation of thiohydrazide analogues with 4-bromo-3, 6-dichloropyridazine: an efficient rout to pyridazino[4, 3-e][1, 3, 4]thiadiazines.