Reaction of benzoylpyruvate with a mixture of aromatic aldehydes and 5-amino-1,3,4-thiadizole-2-thiol

Subject Areas :

1 - Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran
2 - Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran

Received: 2017-03-13 Accepted : 2017-05-12 Published : 2017-03-01

Keywords: Benzoylpyruvate, Aromatic aldehydes, 5-amino-1, 3, 4-thiadizole-2-thiol, Multi-component reactions (MCRs),

Abstract :

Reactions of benzoylpyruvate with a mixture of aromatic aldehydes and 5-amino-1,3,4-thiadizole-2-thiol in a 1:1:1 molar ratio, afforded 5-(5-aryl-4-benzoyl-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-1,3,4-thiadizole-2-thiols (3a-c). The structure of the resulted products was confirmed by determination of the melting point and spectrophotometric techniques such as IR and 1H-NMR spectroscopy.

References:

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Reaction of benzoylpyruvate with a mixture of aromatic aldehydes and 5-amino-1,3,4-thiadizole-2-thiol