Simple and efficient Heterocyclization method for Synthesis of new pyrimido thiadiazine-3,7-diamine derivatives

Subject Areas :

1 - Factually of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Received: 2018-09-10 Accepted : 2018-11-19 Published : 2018-12-04

Keywords: heterocyclization, phenylthioisothiocyanate, methylpyrimidine, methylhydrazine,

Abstract :

New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine were synthesized via the cyclo condensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines in simple and efficient methods.

References:

Synthesis and spectroscopic study of a new diamidophosphoester, (4-CH3-C6H4O)((CH3)2CHNH)2P(O)
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One-pot synthesis of 1,2,4,5-tetrasubstituted Imidazoles using BiFeO3
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Tributyl hexadecyl phosphonium bromide as a new and efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidinones/thiones via a three component condensation reactions
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Theoretical study of HCX (NH2) (X= O, S, and Se) analogs in the gas phase: Electronic Structure, Natural Bond Orbital (NBO) & Natural Resonance Theory (NRT)
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Synthesis 3 and 4-Dihydropyrimidinone and Thiones using Multi-Walled Carboxylated Carbon Nanotube Catalysts
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Study of the effects of solvent and temperature on the Connections of the MTX and L-FMTX with single-walled carbon nanotubes using QM and MM
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Simple and efficient Heterocyclization method for Synthesis of new pyrimido thiadiazine-3,7-diamine derivatives