One-Pot Synthesis of Phenytoin Analogs in soilution Conditions

Subject Areas :

Alireza Kiasat ¹ (Department of Chemistry , Shahid Chamran University , Ahvaz , Iran)
Maryam Nikmanesh ² (Department of Chemistry , Shahid Chamran University , Ahvaz , Iran)

Received: 2013-01-14 Accepted : 2013-05-14 Published : 2013-06-01

Keywords: Green Chemistry, Synthesis, solvent free, Phenytoin, Grinding,

Abstract :

phenytoine derivatives were synthesized , via the pinacol condensation with thereaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thioureain presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle atroom temperatures. The reaction was completed at short reaction times (approximately15min) and pure products were obtained with high yields (81-94%).

References:

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One-Pot Synthesis of Phenytoin Analogs in soilution Conditions