Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds

Subject Areas :

Mohammad Hosein Farjam ¹ (Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran)
Ramin Rezaei ² (Department of Chemistry , Firoozabad Branch, Islamic Azad University, Firoozabad, Iran)

Received: 2016-06-01 Accepted : 2016-06-01 Published : 2012-05-01

Keywords: Solvent-free, One-pot, Biginelli reaction, Dihydropyrimidinones,

Abstract :

An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.

References:

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Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds