reaction of thiohydantoins and ethylbromopyruvate for Synthesis of imidazo[2,1-b]thiazole 3-carboxylate

Subject Areas :

Nasimeh Zarei ¹ , Mohammad Mehdi Ghanbari ² , Marzieh Jamali ³ , Mahboobeh Kiamarsi ⁴ , Pegah Mohagheghzadeh ⁵

1 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran,
2 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
3 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
4 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
5 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

Received: 2014-11-19 Accepted : 2015-05-02 Published : 2015-04-01

Keywords: Thiohydantoin, Imidazo[2, 1-b]thiazole, Ethylbromopyruvate, anticancer, Thioxoimidazolidin,

Abstract :

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions

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