Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives

Subject Areas :

Javad Azizian ¹ , Ramin Miri ² , Mohammad Kazem Mohammadi ³

1 - Factually of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.
2 - Medicinal & Natural Products Chemistry Research Center , Shiraz University of Medical Sciences , Shiraz , Iran
3 - Factually of science , Ahvaz Branch Islamic Azad University , Ahvaz , Iran .

Received: 2014-01-14 Accepted : 2014-05-14 Published : 2014-06-01

Keywords: heterocyclization, 5-Bromo-2, 4-dichloro-6-methylpyrimidine, Pyrimido[4, 5-e][1, 3, 4]thiadiazine, Binucleophile, Bielectrophile,

Abstract :

New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the construction of such heterocyclic ring systems.

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