Convenient synthesis of tetrazolo[1,5-b]pyridazine derivatives

Subject Areas :

1 - Department of Chemistry, Faculty of Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran
2 - Department of Chemistry, Faculty of Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

Received: 2022-02-03 Accepted : 2022-02-03 Published : 2021-03-01

Keywords: Hydrazine, diazotization, 3, 6-dichloropyridazine, tetrazolo[1, 5-b]pyridazine,

Abstract :

Reaction of 3,6-dichloropyridazine with hydrazine gave 1-(6-chloropyridazin-3-yl) hydrazine in high yield in ethanol at room temperature. Diazotization of the latter compound converted it to 6-chlorotetrazolo[1,5-b]pyridazine quantitatively in ice bath. 6-Chlorotetrazolo[1,5-b]pyridazine underwent a chlorine substitution is ethanol with amines at room temperature.The reaction mechanism and spectral data is discussed.

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Synthesis and spectroscopic study of a new diamidophosphoester, (4-CH3-C6H4O)((CH3)2CHNH)2P(O)
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Convenient synthesis of tetrazolo[1,5-b]pyridazine derivatives