A Novel, Heterogeneous Catalyst for the One-Pot Synthesis of 1,8-Dioxodecahydroacridine Derivatives Under Solvent-Free Conditions
Subject Areas :
Tayebeh Sanaeishoar
1
(Department of Chemistry, College of Science, Khouzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran)
Mitra Saremi
2
(Department of Chemistry, College of Science, Khouzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran)
Keywords: Solvent-free, 1, Multicomponent, One-pot synthesis, Hantzsch, 8-Dioxohexahydroacridine,
Abstract :
An efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst.